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本文引用的文献

1
Antistaphylococcal activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic.TD-1792，一种多价糖肽-头孢菌素抗生素的抗葡萄球菌活性。
Antimicrob Agents Chemother. 2012 Mar;56(3):1584-7. doi: 10.1128/AAC.05532-11. Epub 2011 Dec 27.
2
In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates.新型多价糖肽-头孢菌素抗生素 TD-1792 对耐万古霉素葡萄球菌分离株的体外活性。
Antimicrob Agents Chemother. 2010 Sep;54(9):3799-803. doi: 10.1128/AAC.00452-10. Epub 2010 Jun 28.
3
Exploring the positional attachment of glycopeptide/beta-lactam heterodimers.探索糖肽/β-内酰胺异二聚体的位置连接。
J Antibiot (Tokyo). 2008 Oct;61(10):603-14. doi: 10.1038/ja.2008.80.
4
In vitro activity of tigecycline against strains isolated from diabetic foot ulcers.替加环素对从糖尿病足溃疡分离出的菌株的体外活性。
Pathol Biol (Paris). 2007 Nov;55(8-9):398-406. doi: 10.1016/j.patbio.2007.07.003. Epub 2007 Oct 1.
5
New antimicrobial agents as therapy for resistant gram-positive cocci.新型抗菌药物用于耐药革兰氏阳性球菌的治疗
Eur J Clin Microbiol Infect Dis. 2008 Jan;27(1):3-15. doi: 10.1007/s10096-007-0389-y.
6
Dalbavancin, a long-acting lipoglycopeptide for the treatment of multidrug-resistant Gram-positive bacteria.达巴万星，一种用于治疗多重耐药革兰氏阳性菌的长效脂糖肽。
Expert Rev Anti Infect Ther. 2007 Aug;5(4):557-71. doi: 10.1586/14787210.5.4.557.
7
Bacteriology of moderate-to-severe diabetic foot infections and in vitro activity of antimicrobial agents.中重度糖尿病足感染的细菌学及抗菌药物的体外活性
J Clin Microbiol. 2007 Sep;45(9):2819-28. doi: 10.1128/JCM.00551-07. Epub 2007 Jul 3.
8
In vitro activities of dalbavancin and 12 other agents against 329 aerobic and anaerobic gram-positive isolates recovered from diabetic foot infections.达巴万星及其他12种药物对从糖尿病足感染中分离出的329株需氧和厌氧革兰氏阳性菌的体外活性。
Antimicrob Agents Chemother. 2006 Aug;50(8):2875-9. doi: 10.1128/AAC.00286-06.
9
Ertapenem versus piperacillin/tazobactam for diabetic foot infections (SIDESTEP): prospective, randomised, controlled, double-blinded, multicentre trial.厄他培南对比哌拉西林/他唑巴坦治疗糖尿病足感染（SIDESTEP）：前瞻性、随机、对照、双盲、多中心试验
Lancet. 2005 Nov 12;366(9498):1695-703. doi: 10.1016/S0140-6736(05)67694-5.
10
In vitro activities of the new semisynthetic glycopeptide telavancin (TD-6424), vancomycin, daptomycin, linezolid, and four comparator agents against anaerobic gram-positive species and Corynebacterium spp.新型半合成糖肽类药物特拉万星（TD-6424）、万古霉素、达托霉素、利奈唑胺以及四种对照药物对厌氧革兰氏阳性菌和棒状杆菌属的体外活性
Antimicrob Agents Chemother. 2004 Jun;48(6):2149-52. doi: 10.1128/AAC.48.6.2149-2152.2004.

TD-1792 体外活性研究，一种多价糖肽-头孢菌素抗生素，针对 377 株厌氧菌和 34 株棒状杆菌属细菌。

In vitro activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic, against 377 strains of anaerobic bacteria and 34 strains of Corynebacterium species.

机构信息

R. M. Alden Research Lab, Culver City, California, USA.

出版信息

Antimicrob Agents Chemother. 2012 Apr;56(4):2194-7. doi: 10.1128/AAC.06274-11. Epub 2012 Jan 30.

DOI:10.1128/AAC.06274-11
PMID:22290981
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3318369/
Abstract

TD-1792 is a multivalent glycopeptide-cephalosporin heterodimer antibiotic with potent activity against Gram-positive bacteria. We tested TD-1792 against 377 anaerobes and 34 strains of Corynebacterium species. Against nearly all Gram-positive strains, TD-1792 had an MIC₉₀ of 0.25 μg/ml and was typically 3 to 7 dilutions more active than vancomycin and daptomycin.

摘要

TD-1792 是一种多价糖肽-头孢菌素杂合二聚体抗生素，对革兰氏阳性菌具有强大的活性。我们测试了 TD-1792 对 377 株厌氧菌和 34 株棒状杆菌属细菌的活性。几乎所有革兰氏阳性菌的 TD-1792 的 MIC₉₀ 为 0.25 μg/ml，与万古霉素和达托霉素相比，通常具有 3 至 7 倍的活性。