Meisel Peter, Kohlmann Thomas, Wallaschofski Henri, Kroemer Heyo K, Kocher Thomas
Department of Pharmacology, University of Greifswald, 17475 Greifswald, Germany.
ISRN Dent. 2011;2011:125168. doi: 10.5402/2011/125168. Epub 2011 Nov 16.
Common risk factors of periodontitis and cardiovascular diseases fuel the debate on interrelationships between them. The aim is to prove whether statins may influence periodontal parameters by affecting either of these factors. Out of the 4,290 subjects of SHIP (Study of Health in Pomerania), we included subjects aged >30 years (219 with statins, 2937 without) and excluded edentulous. We determined periodontal measures, cholesterol fractions, and inflammation markers. Statin use and periodontal risk factors were assessed. Gingival plaque and periodontal attachment loss were associated with systemic LDL cholesterol (P < 0.001) and C-reactive protein CRP (P = 0.019) revealing interaction with statin use. When adjusted for age, sex, smoking, diabetes, education, and dental service, statins were identified as effect modifiers abolishing the relationship between attachment loss and LDL and between gingival plaque and LDL (interactions P < 0.001). No statin-related interaction was detected with increase in CRP. The interaction supports the view of inter-relationships between periodontal and systemic inflammatory mediators.
牙周炎和心血管疾病的常见风险因素引发了关于它们之间相互关系的争论。目的是证明他汀类药物是否可能通过影响这些因素中的任何一个来影响牙周参数。在SHIP（波美拉尼亚健康研究）的4290名受试者中，我们纳入了年龄大于30岁的受试者（219名使用他汀类药物，2937名未使用），并排除了无牙者。我们测定了牙周指标、胆固醇组分和炎症标志物。评估了他汀类药物的使用情况和牙周风险因素。牙龈菌斑和牙周附着丧失与全身低密度脂蛋白胆固醇（P < 0.001）和C反应蛋白CRP（P = 0.019）相关，揭示了与他汀类药物使用的相互作用。在对年龄、性别、吸烟、糖尿病、教育程度和牙科服务进行校正后，他汀类药物被确定为效应修饰因素，消除了附着丧失与低密度脂蛋白之间以及牙龈菌斑与低密度脂蛋白之间的关系（相互作用P < 0.001）。未检测到与CRP升高相关的他汀类药物相互作用。这种相互作用支持了牙周和全身炎症介质之间存在相互关系的观点。
