Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, 4072, Australia.
Curr Drug Targets. 2012 Mar;13(3):373-87. doi: 10.2174/138945012799424624.
The emergence of multi-drug resistant bacteria is one of the most critical medical problems currently facing humankind, which will only get worse if no new antibacterial drugs are launched. This article will first review commonly used screening strategies used to identify potential new antibiotics and then discuss novel screening methods. In addition, new assays, methods, biological targets and compounds with novel modes of action undergoing pre-clinical or clinical development are briefly discussed.
耐药菌的出现是目前人类面临的最严重的医学问题之一，如果不推出新的抗菌药物，情况只会变得更糟。本文首先回顾了常用于鉴定潜在新抗生素的常用筛选策略，然后讨论了新的筛选方法。此外，还简要讨论了正在临床前或临床开发阶段的具有新型作用模式的新检测、方法、生物靶标和化合物。
