铼催化吲哚与末端炔烃的区域选择性加成反应。
Rhenium-catalyzed regiodivergent addition of indoles to terminal alkynes.
机构信息
Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
Org Lett. 2012 Jan 20;14(2):588-91. doi: 10.1021/ol203199m. Epub 2011 Dec 29.
PMID:22206463
Abstract
An efficient rhenium-catalyzed site-switchable addition of indoles to terminal alkynes is described. A variety of bisindolylalkane derivatives are expeditiously synthesized in high yields with excellent regioselectivity. Preliminary mechanistic study sheds light on the observed regiodivergent addition.
摘要
本文描述了一种高效的铼催化吲哚与末端炔烃的位点可切换加成反应。通过该方法可以高收率、优异的区域选择性地快速合成多种双吲哚基链烷烃衍生物。初步的机理研究阐明了观察到的区域发散加成反应。
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