Deb Barnali, Debnath Sudhan, Chakraborty Ankita, Majumdar Swapan
Department of Chemistry, Tripura University Suryamaninagar 799 022 India
Department of Chemistry, Netaji Subhash Mahavidalaya Tripura 799114 India.
RSC Adv. 2021 Sep 16;11(49):30827-30839. doi: 10.1039/d1ra05679d. eCollection 2021 Sep 14.
We report herein an operationally simple, efficient and versatile procedure for the synthesis of bis-indolylmethanes the reaction of indoles with aldehydes or ketones in the presence of silica-supported ferric chloride under grindstone conditions. The prepared supported catalyst was characterized by SEM and EDX spectroscopy. The present protocol has several advantages such as shorter reaction time, high yield, avoidance of using harmful organic solvents during the reaction and tolerance of a wide range of functional groups. Molecular docking studies targeted toward the binding site of SARS-CoV-2 main protease (3CL or M) enzymes were investigated with the synthesized bis-indoles. Our study revealed that some of the synthesized compounds have potentiality to inhibit the SARS-CoV-2 M enzyme by interacting with key amino acid residues of the active sites hydrophobic as well as hydrogen bonding interactions.
我们在此报告一种操作简单、高效且通用的合成双吲哚甲烷的方法，即在磨盘条件下，吲哚与醛或酮在二氧化硅负载的氯化铁存在下反应。通过扫描电子显微镜（SEM）和能量散射X射线光谱（EDX）对制备的负载型催化剂进行了表征。本方法具有几个优点，如反应时间短、产率高、反应过程中避免使用有害有机溶剂以及对多种官能团具有耐受性。用合成的双吲哚对针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）主要蛋白酶（3CL或M）酶结合位点的分子对接研究进行了考察。我们的研究表明，一些合成化合物有可能通过与活性位点的关键氨基酸残基相互作用（疏水相互作用以及氢键相互作用）来抑制SARS-CoV-2 M酶。
