Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
Org Lett. 2012 Jan 20;14(2):452-5. doi: 10.1021/ol202884z. Epub 2011 Dec 29.
A highly efficient copper-catalyzed aerobic oxidative intramolecular C-H amination has been developed using substituted 2-(1H-imidazol-1-yl)-N-alkylbenzenamines as the starting materials, and the corresponding imidazobenzimidazole derivatives were obtained in excellent yields. This is an economical and practical method for the construction of N-heterocycles.
发展了一种高效的铜催化有氧氧化分子内 C-H 胺化反应，使用取代的 2-(1H-咪唑-1-基)-N-烷基苯甲胺作为起始原料，得到了相应的咪唑并苯并咪唑衍生物，产率优异。这是一种经济实用的构建 N-杂环化合物的方法。
