铜催化一锅法合成咪唑并/苯并咪唑喹唑啉酮的顺序 Ullmann 型偶联和分子内 C-H 酰胺化反应。
Copper-catalyzed one-pot synthesis of imidazo/benzoimidazoquinazolinones by sequential Ullmann-type coupling and intramolecular C-H amidation.
机构信息
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P.R. China
出版信息
Chemistry. 2012 Jan 23;18(4):1180-6. doi: 10.1002/chem.201102794. Epub 2011 Dec 21.
PMID:22190047
Abstract
A simple, practical, and highly efficient copper-catalyzed one-pot synthesis of imidazo/benzoimidazoquinazolinones has been developed. The procedure is based on a sequential copper-catalyzed Ullmann-type N-arylation and aerobic oxidative intramolecular C-H amidation. This method should provide a new and useful strategy for construction of N-heterocycles.
摘要
一种简单、实用、高效的铜催化一锅法合成咪唑并/苯并咪唑并喹唑啉酮的方法已经开发出来。该方法基于顺序的铜催化乌尔曼型 N-芳基化和有氧氧化分子内 C-H 酰胺化。该方法为构建 N-杂环化合物提供了一种新的有用策略。
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