Department of Human Anatomy, Medical University of Bialystok, Bialystok, Poland.
Med Sci Monit. 2012 Jan;18(1):BR54-59. doi: 10.12659/msm.882204.
Tumor growth in multiple myeloma (MM) is regulated by the cytokine networks which are produced by myeloma cells and the microenvironment of the bone marrow. Interleukin-17 (IL-17) is implicated in the increased angiogenesis in the bone marrow of MM. Recent studies reported elevated levels of interleukin 17A (IL-17A) in the sera of patients with advanced stages according to Durie-Salmon classification.
MATERIAL/METHODS: We compared the concentration of IL-17A and IL-17E in the blood serum of 34 newly diagnosed MM patients with healthy subjects' sera. We also evaluated the concentration of IL-17A and IL-17E in the blood serum of MM patients and the relation to the percentage of plasma cells and other clinical parameters. The concentration of IL-17E and IL-17A of healthy subjects and patients with MM was assessed by enzyme-linked immunosorbent assay (ELISA).
Our data confirm that IL-17A and IL-17E serum levels were significantly higher in all MM patients and also in patients with advanced stage compared with healthy subjects. We found the correlation between serum levels of IL-17A in MM patients and percentage of plasma cells. Our results also showed that if serum levels of IL-17E were higher in MM patients, the percentage of plasma cells and beta-2-microglobulin levels were lower.
The IL-17 family of cytokines may suppress or promote tumor growth. There seems to be some balance between the effects of IL-17A and IL-17E. The role of increased levels of IL-17E needs further investigation to understand its role in the pathobiology of MM.
多发性骨髓瘤（MM）中的肿瘤生长受骨髓瘤细胞产生的细胞因子网络和骨髓微环境调节。白细胞介素-17（IL-17）与 MM 骨髓中血管生成增加有关。最近的研究报告称，根据 Durie-Salmon 分类，处于晚期的患者血清中白细胞介素 17A（IL-17A）水平升高。
材料/方法：我们比较了 34 例新诊断的 MM 患者和健康受试者血清中 IL-17A 和 IL-17E 的浓度。我们还评估了 MM 患者血清中 IL-17A 和 IL-17E 的浓度及其与浆细胞百分比和其他临床参数的关系。采用酶联免疫吸附试验（ELISA）检测健康受试者和 MM 患者的 IL-17E 和 IL-17A 浓度。
我们的数据证实，所有 MM 患者和晚期患者的血清 IL-17A 和 IL-17E 水平均显著高于健康受试者。我们发现 MM 患者血清中 IL-17A 水平与浆细胞百分比之间存在相关性。我们的结果还表明，如果 MM 患者血清中 IL-17E 水平较高，则浆细胞百分比和β-2-微球蛋白水平较低。
白细胞介素-17 细胞因子家族可能抑制或促进肿瘤生长。IL-17A 和 IL-17E 的作用之间似乎存在某种平衡。需要进一步研究增加的 IL-17E 水平，以了解其在 MM 发病机制中的作用。
