辅助性T细胞分化的调控机制：从白细胞介素17家族细胞因子中获得的新认识
Regulatory mechanisms of helper T cell differentiation: new lessons learned from interleukin 17 family cytokines.
作者信息
Pappu Bhanu P, Angkasekwinai Pornpimon, Dong Chen
机构信息
Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA.
出版信息
Pharmacol Ther. 2008 Mar;117(3):374-84. doi: 10.1016/j.pharmthera.2007.12.003. Epub 2008 Jan 19.
Abstract
Interleukin 17 (IL-17) family consists of six cytokines in mammals. Among them, IL-17 and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play critical function in inflammation and autoimmunity. On the other hand, IL-17E, also called IL-25, has been associated with allergic responses. Here we summarize recent work by us as well as other investigators in understanding the regulation and function of these three cytokines. From these studies, IL-17 family cytokines may serve as novel targets for pharmaceutical intervention of immune and inflammatory diseases.
摘要
白细胞介素17（IL-17）家族在哺乳动物中由六种细胞因子组成。其中，IL-17和IL-17F由一类新的CD4 +辅助性T（Th）细胞表达，并在炎症和自身免疫中发挥关键作用。另一方面，IL-17E，也称为IL-25，与过敏反应有关。在这里，我们总结了我们自己以及其他研究人员最近在了解这三种细胞因子的调节和功能方面所做的工作。从这些研究来看，IL-17家族细胞因子可能成为免疫和炎症性疾病药物干预的新靶点。
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