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本文引用的文献

1
Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis.IL-27对致脑炎性Th17细胞及实验性自身免疫性脑脊髓炎效应期的抑制作用
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Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.白细胞介素1β和6而非转化生长因子β对于产生白细胞介素17的人辅助性T细胞的分化至关重要。
Nat Immunol. 2007 Sep;8(9):942-9. doi: 10.1038/ni1496. Epub 2007 Aug 5.
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Development, cytokine profile and function of human interleukin 17-producing helper T cells.人白细胞介素17产生辅助性T细胞的发育、细胞因子谱及功能
Nat Immunol. 2007 Sep;8(9):950-7. doi: 10.1038/ni1497. Epub 2007 Aug 5.
4
The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4.炎性辅助性T细胞17（T(H)-17）的发育需要干扰素调节因子4。
Nat Immunol. 2007 Sep;8(9):958-66. doi: 10.1038/ni1500. Epub 2007 Aug 5.
5
IL-17A versus IL-17F induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in AGS gastric adenocarcinoma cells.白细胞介素-17A与白细胞介素-17F在AGS胃腺癌细胞中诱导的细胞内信号转导途径以及白细胞介素-17RA和白细胞介素-17RC RNA干扰的调节作用
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6
Cutting edge: opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppression.前沿：白细胞介素-1和白细胞介素-2对白细胞介素-17+T细胞库调节的相反作用——白细胞介素-1颠覆白细胞介素-2介导的抑制作用。
J Immunol. 2007 Aug 1;179(3):1423-6. doi: 10.4049/jimmunol.179.3.1423.
7
IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells.白细胞介素-25通过增强胸腺基质淋巴细胞生成素依赖性树突状细胞激活的辅助性T细胞2记忆细胞的扩增和功能来增强2型免疫反应。
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Anti-TNF antibodies for Crohn's disease--in pursuit of the perfect clinical trial.用于克罗恩病的抗TNF抗体——追求完美的临床试验。
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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells.白细胞介素-21在炎症性T细胞生成中的关键自分泌调节作用。
Nature. 2007 Jul 26;448(7152):480-3. doi: 10.1038/nature05969. Epub 2007 Jun 20.
10
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.白细胞介素-21启动一条诱导促炎性辅助性T细胞17（TH17）细胞的替代途径。
Nature. 2007 Jul 26;448(7152):484-487. doi: 10.1038/nature05970. Epub 2007 Jun 20.

辅助性T细胞分化的调控机制：从白细胞介素17家族细胞因子中获得的新认识

Regulatory mechanisms of helper T cell differentiation: new lessons learned from interleukin 17 family cytokines.

作者信息

Pappu Bhanu P, Angkasekwinai Pornpimon, Dong Chen

机构信息

Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA.

出版信息

Pharmacol Ther. 2008 Mar;117(3):374-84. doi: 10.1016/j.pharmthera.2007.12.003. Epub 2008 Jan 19.

DOI:10.1016/j.pharmthera.2007.12.003
PMID:18280574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2276145/
Abstract

Interleukin 17 (IL-17) family consists of six cytokines in mammals. Among them, IL-17 and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play critical function in inflammation and autoimmunity. On the other hand, IL-17E, also called IL-25, has been associated with allergic responses. Here we summarize recent work by us as well as other investigators in understanding the regulation and function of these three cytokines. From these studies, IL-17 family cytokines may serve as novel targets for pharmaceutical intervention of immune and inflammatory diseases.

摘要

白细胞介素17（IL-17）家族在哺乳动物中由六种细胞因子组成。其中，IL-17和IL-17F由一类新的CD4 +辅助性T（Th）细胞表达，并在炎症和自身免疫中发挥关键作用。另一方面，IL-17E，也称为IL-25，与过敏反应有关。在这里，我们总结了我们自己以及其他研究人员最近在了解这三种细胞因子的调节和功能方面所做的工作。从这些研究来看，IL-17家族细胞因子可能成为免疫和炎症性疾病药物干预的新靶点。