Allen M L, McIntosh D L, Robinson M G
Oklahoma Foundation for Digestive Research and Presbyterian Hospital, Oklahoma City.
Am J Gastroenterol. 1990 Oct;85(10):1331-4.
There is conflicting evidence regarding whether lower esophageal sphincter and esophageal contractile pressures are affected by changes in the severity of gastroesophageal reflux disease. We compared the manometric and endoscopic findings from 30 patients before and after treatment for esophagitis. Before treatment, the grade of esophagitis (I-III) was significantly correlated (r = -0.37; p less than 0.05) with lower esophageal sphincter pressure, but not with esophageal contractile pressure. After treatment, the grade of esophagitis did not change or became worse in 15 patients, and became better in 15 patients. Of these, seven healed. The group that showed no endoscopic improvement demonstrated no change in lower esophageal sphincter or esophageal contractile pressures. The group that did show endoscopic improvement also demonstrated no increase in lower esophageal sphincter or esophageal contractile pressures, and this was particularly evident in those whose esophagitis healed. These data suggest that healing of esophagitis does not result in improvement of esophageal motor function.
关于胃食管反流病严重程度的变化是否会影响食管下括约肌和食管收缩压，目前存在相互矛盾的证据。我们比较了30例食管炎患者治疗前后的测压和内镜检查结果。治疗前，食管炎的分级（I - III级）与食管下括约肌压力显著相关（r = -0.37；p小于0.05），但与食管收缩压无关。治疗后，15例患者的食管炎分级未改变或加重，15例患者的食管炎分级改善。其中，7例愈合。内镜检查未改善的组食管下括约肌或食管收缩压无变化。内镜检查确实改善的组食管下括约肌或食管收缩压也没有升高，这在食管炎愈合的患者中尤为明显。这些数据表明，食管炎的愈合并不会导致食管运动功能的改善。
