Katz P O, Knuff T E, Benjamin S B, Castell D O
Am J Gastroenterol. 1986 Sep;81(9):744-6.
Thirteen patients with gastroesophageal reflux disease underwent esophageal manometric evaluation during acute exacerbations and disease remission to evaluate lower esophageal sphincter and peristaltic pressure in response to treatment. No change was noted in lower esophageal sphincter pressure (15.2 +/- 2.6 mg versus 14.3 +/- 1.8 mm Hg) or peristaltic pressure (64.1 +/- 6.9 versus 62.1 +/- 7/8 mm Hg) with remission while both lower esophageal sphincter pressure and distal amplitude were lower in reflux patients than controls (p less than 0.05). Short-term treatment resulting in endoscopic and symptom improvement of gastroesophageal reflux disease does not appear to improve lower esophageal sphincter and peristaltic pressure.
13例胃食管反流病患者在疾病急性加重期和缓解期接受了食管测压评估，以评估治疗后食管下括约肌和蠕动压力。缓解期时，食管下括约肌压力（15.2±2.6 mmHg对14.3±1.8 mmHg）或蠕动压力（64.1±6.9对62.1±7.8 mmHg）未发现变化，而反流患者的食管下括约肌压力和远端振幅均低于对照组（p<0.05）。导致胃食管反流病内镜及症状改善的短期治疗似乎并未改善食管下括约肌和蠕动压力。
