Haghi-Ashtiani Mohammad Taghi, Mamishi Setareh, Shayanfar Nasrin, Mohammadpour Masoud, Yaghmaei Bahareh, Abedini Mina, Farahani Narges Node, Rezaei Nima
Tehran University of Medical Sciences, Children's Medical Center Tehran, Iran.
Acta Microbiol Immunol Hung. 2011 Dec;58(4):273-8. doi: 10.1556/AMicr.58.2011.4.3.
Bacterial meningitis continues to be associated with high morbidity and mortality rate worldwide, especially in the pediatric age group. This study was performed to identify the microbial etiologies of meningitis among 31 children, who were admitted in the Emergency Ward of a referral pediatric hospital in Iran. Culture identification showed that Streptococcus pneumoniae (12 subjects), Haemophilus influenzae (11 subjects) were the most common bacteria, followed by Escherichia coli (7 cases) and Neisseria meningitidis (only one case). Antibiotic susceptibility tests revealed that vancomycin had the best effect on S. pneumoniae in comparison with other antibiotics, whereas H. influenzae and E. coli were more susceptible to ceftriaxone, ceftazidime, and ceftizoxime than other antibiotics. In conclusion, despite the advances in antibiotic therapy and vaccine development, bacterial meningitis still is a health problem. S. pneumoniae, H. influenzae, and N. meningitidis are the main sources of bacterial meningitis, but other organisms such as E. coli should also be suspected, when a case is admitted to a referral pediatric hospital.
在全球范围内，细菌性脑膜炎仍然与高发病率和死亡率相关，尤其是在儿童年龄组中。本研究旨在确定伊朗一家转诊儿科医院急诊病房收治的31名儿童脑膜炎的微生物病因。培养鉴定显示，肺炎链球菌（12例）、流感嗜血杆菌（11例）是最常见的细菌，其次是大肠杆菌（7例）和脑膜炎奈瑟菌（仅1例）。抗生素敏感性试验表明，与其他抗生素相比，万古霉素对肺炎链球菌的效果最佳，而流感嗜血杆菌和大肠杆菌对头孢曲松、头孢他啶和头孢唑肟的敏感性高于其他抗生素。总之，尽管抗生素治疗和疫苗开发取得了进展，但细菌性脑膜炎仍然是一个健康问题。肺炎链球菌、流感嗜血杆菌和脑膜炎奈瑟菌是细菌性脑膜炎的主要来源，但当病例收治于转诊儿科医院时，也应怀疑其他病原体，如大肠杆菌。
