表观遗传学精神药理学的现状与展望。
Current status and future prospects for epigenetic psychopharmacology.
机构信息
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands.
出版信息
Epigenetics. 2012 Jan 1;7(1):20-8. doi: 10.4161/epi.7.1.18688.
Abstract
Mounting evidence suggest that epigenetic regulation of brain functions is important in the etiology of psychiatric disorders. These epigenetic regulatory mechanisms, such as DNA methylation and histone acetylation, are influenced by many pharmaceutical compounds including psychiatric drugs. It is therefore of interest to investigate how psychiatric drugs are of influence and what the potential is of new epigenetic drugs for psychiatric disorders. With this targeted review we summarize the current state of knowledge in order to provide insight in this developing field. Several traditional psychiatric drugs have been found to alter the epigenome and in a variety of animal studies, experimental compounds with epigenetic targets have been investigated as potential psychiatric drugs. After discussion of the most relevant epigenetic mechanisms we present the evidence for epigenetic effects for the most relevant classes of drugs.
摘要
越来越多的证据表明，脑功能的表观遗传调控在精神障碍的发病机制中很重要。这些表观遗传调控机制，如 DNA 甲基化和组蛋白乙酰化，受许多药物化合物的影响，包括精神药物。因此，研究精神药物的影响以及新的针对精神障碍的表观遗传药物的潜力是很有意义的。通过本次有针对性的综述，我们总结了目前的知识状况，以便深入了解这一不断发展的领域。一些传统的精神药物已被发现可以改变表观基因组，在各种动物研究中，具有表观遗传靶点的实验化合物已被作为潜在的精神药物进行研究。在讨论了最相关的表观遗传机制之后，我们介绍了最相关药物类别的表观遗传效应证据。
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