Zhang Xiu-Jun, Liu Mei-Ling, Jia Meng-Chun
National Research Institute for Family Planning, Beijing, China.
Yi Chuan. 2011 Dec;33(12):1300-7. doi: 10.3724/sp.j.1005.2011.01300.
Mammalian spermatogenesis is a highly complex cell division and differentiation process occurring in the seminiferous tubules of the testis. This processes are regulated at both transcriptional and post-transcriptional levels, any mistake in this process can lead to infertility. Unveiling the molecular mechanisms of spermatogenesis has important implications for exploring novel contraceptive approach and treatment of infertility. This review addresses recent progress towards understanding the regulation of androgen, estrogen and their receptors, transcription factors and chromatin-associated factors for spermatogenesis at transcriptional level.
哺乳动物的精子发生是一个在睾丸生精小管中发生的高度复杂的细胞分裂和分化过程。这个过程在转录和转录后水平都受到调控，该过程中的任何错误都可能导致不育。揭示精子发生的分子机制对于探索新型避孕方法和治疗不育症具有重要意义。这篇综述阐述了在转录水平上理解雄激素、雌激素及其受体、转录因子和染色质相关因子对精子发生调控的最新进展。
