Sahlu Bahlibi Weldegebriall, Zhao Shanjiang, Wang Xiuge, Umer Saqib, Zou Huiying, Huang Jinming, Zhu Huabin
1Embryo Biotechnology and Reproduction Laboratory, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193 People's Republic of China.
Tigray Agricultural Research Institute, Mekelle Agricultural Research Center, Mekelle, Ethiopia.
J Anim Sci Biotechnol. 2020 Feb 28;11:16. doi: 10.1186/s40104-019-0424-8. eCollection 2020.
Spermatogenesis is a complex differentiating developmental process in which undifferentiated spermatogonial germ cells differentiate into spermatocytes, spermatids, and finally, to mature spermatozoa. This multistage developmental process of spermatogenesis involves the expression of many male germ cell-specific long noncoding RNAs (lncRNAs) and highly regulated and specific gene expression. LncRNAs are a recently discovered large class of noncoding cellular transcripts that are still relatively unexplored. Only a few of them have post-meiotic; however, lncRNAs are involved in many cellular biological processes. The expression of lncRNAs is biologically relevant in the highly dynamic and complex program of spermatogenesis and has become a research focus in recent genome studies. This review considers the important roles and novel regulatory functions whereby lncRNAs modulate mammalian spermatogenesis.
精子发生是一个复杂的分化发育过程，在此过程中，未分化的精原生殖细胞分化为精母细胞、精子细胞，最终发育为成熟的精子。精子发生的这一多阶段发育过程涉及许多雄性生殖细胞特异性长链非编码RNA（lncRNA）的表达以及高度调控的特异性基因表达。lncRNA是最近发现的一大类非编码细胞转录本，目前仍相对未被充分研究。其中只有少数在减数分裂后发挥作用；然而，lncRNA参与许多细胞生物学过程。lncRNA的表达在高度动态和复杂的精子发生程序中具有生物学相关性，并且已成为近期基因组研究的一个焦点。本综述探讨了lncRNA调节哺乳动物精子发生的重要作用和新的调控功能。
