Hawaii Center for AIDS, University of Hawaii-Manoa, Honolulu, HI, USA.
J Neurovirol. 2012 Feb;18(1):69-73. doi: 10.1007/s13365-011-0068-8. Epub 2011 Dec 30.
HIV-associated neurocognitive disorders (HAND) persist despite plasma HIV RNA suppression with antiretrovirals (ARV). Sequestered reservoirs in the central nervous system and circulating monocytes are theorized to contribute to persistent brain injury. We previously demonstrated that elevated intracellular HIV DNA from circulating cells was associated with HAND in ARV-treated and ARV-naive subjects. We now report that failure to suppress intra-monocyte HIV DNA 3.5 years after initiating ARV is linked to persistent HAND and subjects with dementia are least likely to suppress intra-monocyte HIV DNA at 3.5 years. These findings suggest that antiviral strategies may need to target intra-monocyte HIV DNA.
尽管抗逆转录病毒药物（ARV）能抑制 HIV 血浆 RNA，但仍会出现与 HIV 相关的神经认知障碍（HAND）。中枢神经系统中的隔离储存库和循环中的单核细胞被认为会导致持续的脑损伤。我们之前的研究表明，循环细胞中 HIV 细胞内 DNA 的升高与接受 ARV 治疗和未经 ARV 治疗的 HAND 有关。我们现在报告说，在开始接受 ARV 治疗 3.5 年后，未能抑制单核细胞内 HIV DNA 与持续的 HAND 有关，而痴呆症患者在 3.5 年后最不可能抑制单核细胞内 HIV DNA。这些发现表明，抗病毒策略可能需要针对单核细胞内的 HIV DNA。
