聚焦超声破坏血脑屏障：分子神经肿瘤学治疗药物递送的新领域。
Focused ultrasound disruption of the blood-brain barrier: a new frontier for therapeutic delivery in molecular neurooncology.
机构信息
Division of Neurosurgery, Department of Surgery, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
出版信息
Neurosurg Focus. 2012 Jan;32(1):E3. doi: 10.3171/2011.10.FOCUS11252.
Abstract
Recent advances in molecular neurooncology provide unique opportunities for targeted molecular-based therapies. However, the blood-brain barrier (BBB) remains a major limitation to the delivery of tumor-specific therapies directed against aberrant signaling pathways in brain tumors. Given the dismal prognosis of patients with malignant brain tumors, novel strategies that overcome the intrinsic limitations of the BBB are therefore highly desirable. Focused ultrasound BBB disruption is emerging as a novel strategy for enhanced delivery of therapeutic agents into the brain via focal, reversible, and safe BBB disruption. This review examines the potential role and implications of focused ultrasound in molecular neurooncology.
摘要
分子神经肿瘤学的最新进展为靶向分子治疗提供了独特的机会。然而，血脑屏障（BBB）仍然是针对脑肿瘤中异常信号通路的肿瘤特异性治疗药物递送的主要限制。鉴于恶性脑肿瘤患者的预后不佳，因此非常需要克服 BBB 固有局限性的新型策略。聚焦超声 BBB 破坏正在成为一种通过局灶性、可逆和安全的 BBB 破坏将治疗剂递送到大脑中的新策略。本文综述了聚焦超声在分子神经肿瘤学中的潜在作用和意义。
相似文献
1
Focused ultrasound disruption of the blood-brain barrier: a new frontier for therapeutic delivery in molecular neurooncology.
Neurosurg Focus. 2012 Jan;32(1):E3. doi: 10.3171/2011.10.FOCUS11252.
2
Enhanced therapeutic agent delivery through magnetic resonance imaging-monitored focused ultrasound blood-brain barrier disruption for brain tumor treatment: an overview of the current preclinical status.
Neurosurg Focus. 2012 Jan;32(1):E4. doi: 10.3171/2011.10.FOCUS11238.
3
Growth inhibition in a brain metastasis model by antibody delivery using focused ultrasound-mediated blood-brain barrier disruption.
J Control Release. 2016 Sep 28;238:281-288. doi: 10.1016/j.jconrel.2016.08.001. Epub 2016 Aug 3.
4
The role of caveolin-1 in blood-brain barrier disruption induced by focused ultrasound combined with microbubbles.
J Mol Neurosci. 2012 Mar;46(3):677-87. doi: 10.1007/s12031-011-9629-9. Epub 2011 Aug 23.
5
A review of potential applications of MR-guided focused ultrasound for targeting brain tumor therapy.
Neurosurg Focus. 2018 Feb;44(2):E10. doi: 10.3171/2017.11.FOCUS17620.
6
Ultrasound-mediated disruption of the blood tumor barrier for improved therapeutic delivery.
Neoplasia. 2021 Jul;23(7):676-691. doi: 10.1016/j.neo.2021.04.005. Epub 2021 Jun 14.
7
Noninvasive, transient and selective blood-brain barrier opening in non-human primates in vivo.
PLoS One. 2011;6(7):e22598. doi: 10.1371/journal.pone.0022598. Epub 2011 Jul 22.
8
Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood-brain barrier opening and brain-tumor drug delivery.
Acta Biomater. 2015 Mar;15:89-101. doi: 10.1016/j.actbio.2014.12.026. Epub 2015 Jan 7.
9
Ultrasound and Microbubble-Mediated Blood-Brain Barrier Disruption for Targeted Delivery of Therapeutics to the Brain.
Methods Mol Biol. 2018;1831:111-119. doi: 10.1007/978-1-4939-8661-3_9.
10
Blood-brain barrier disruption with low-intensity pulsed ultrasound for the treatment of pediatric brain tumors: a review and perspectives.
Neurosurg Focus. 2020 Jan 1;48(1):E10. doi: 10.3171/2019.10.FOCUS19726.
引用本文的文献
1
Old Tools in a New Era: The Continued Relevance of Chemotherapy in Pediatric Neuro-Oncology.
Curr Oncol. 2025 Jul 20;32(7):410. doi: 10.3390/curroncol32070410.
2
Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group.
Mol Ther Nucleic Acids. 2025 Jan 17;36(1):102457. doi: 10.1016/j.omtn.2025.102457. eCollection 2025 Mar 11.
3
Pediatric neuro-oncology: Highlights of the last quarter-century.
Neoplasia. 2025 Jan;59:101098. doi: 10.1016/j.neo.2024.101098. Epub 2024 Dec 4.
4
A comprehensive review of advanced focused ultrasound (FUS) microbubbles-mediated treatment of Alzheimer's disease.
Heliyon. 2024 Sep 6;10(18):e37533. doi: 10.1016/j.heliyon.2024.e37533. eCollection 2024 Sep 30.
5
Advancements in strategies for overcoming the blood-brain barrier to deliver brain-targeted drugs.
Front Aging Neurosci. 2024 Aug 26;16:1353003. doi: 10.3389/fnagi.2024.1353003. eCollection 2024.
6
Blood-brain barrier alterations and their impact on Parkinson's disease pathogenesis and therapy.
Transl Neurodegener. 2024 Jul 29;13(1):37. doi: 10.1186/s40035-024-00430-z.
7
Macrophages and HLA-Class II Alleles in Multiple Sclerosis: Insights in Therapeutic Dynamics.
Int J Mol Sci. 2024 Jul 4;25(13):7354. doi: 10.3390/ijms25137354.
8
Protocol to Induce the Temporary Opening of the Blood-Brain Barrier with Short-Time Focused Ultrasound in Rats.
Pharmaceutics. 2023 Dec 6;15(12):2733. doi: 10.3390/pharmaceutics15122733.
9
Glioblastoma-on-a-chip construction and therapeutic applications.
Front Oncol. 2023 Jul 12;13:1183059. doi: 10.3389/fonc.2023.1183059. eCollection 2023.
10
Intelligent nanotherapeutic strategies for the delivery of CRISPR system.
Acta Pharm Sin B. 2023 Jun;13(6):2510-2543. doi: 10.1016/j.apsb.2022.12.013. Epub 2022 Dec 22.
本文引用的文献
1
Explorations of high-intensity therapeutic ultrasound and microbubble-mediated gene delivery in mouse liver.
Gene Ther. 2011 Oct;18(10):1006-14. doi: 10.1038/gt.2011.34. Epub 2011 Mar 31.
2
Vascular gene transfer of SDF-1 promotes endothelial progenitor cell engraftment and enhances angiogenesis in ischemic muscle.
Mol Ther. 2011 May;19(5):895-902. doi: 10.1038/mt.2011.18. Epub 2011 Mar 1.
3
MR-guided focused ultrasound for brain ablation and blood-brain barrier disruption.
Methods Mol Biol. 2011;711:579-93. doi: 10.1007/978-1-61737-992-5_30.
4
Nanomedicine.
N Engl J Med. 2010 Dec 16;363(25):2434-43. doi: 10.1056/NEJMra0912273.
5
Targeted gene delivery in tumor xenografts by the combination of ultrasound-targeted microbubble destruction and polyethylenimine to inhibit survivin gene expression and induce apoptosis.
J Exp Clin Cancer Res. 2010 Nov 23;29(1):152. doi: 10.1186/1756-9966-29-152.
6
Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain.
Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15205-10. doi: 10.1073/pnas.1003388107. Epub 2010 Aug 9.
7
Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease.
PLoS One. 2010 May 11;5(5):e10549. doi: 10.1371/journal.pone.0010549.
8
Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment.
Radiology. 2010 May;255(2):415-25. doi: 10.1148/radiol.10090699.
9
Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin.
J Am Chem Soc. 2010 Apr 7;132(13):4678-84. doi: 10.1021/ja908117a.
10
Experimental study on targeted methotrexate delivery to the rabbit brain via magnetic resonance imaging-guided focused ultrasound.
J Ultrasound Med. 2009 Jul;28(7):871-80. doi: 10.7863/jum.2009.28.7.871.
Zotero 插件