Wang Wei, Han Sheng, Yao Zhanpeng, Li Xin, Huang Ping, Zhang Ming, Chen Yan, He Jianjun
Administration of Clinical Research and Teaching, School of Stomatology, Fourth Military Medical University, Xi'an, China.
J Oral Maxillofac Surg. 2012 Sep;70(9):2205-10. doi: 10.1016/j.joms.2011.09.040. Epub 2011 Dec 30.
To analyze the epidemiologic characteristics and recurrence factors of oral squamous cell carcinoma (OSCC) in northwest China.
Patients with OSCC whose first visits to the Stomatology Hospital of the Fourth Military Medical University from January 2007 through December 2008 were investigated. The epidemiologic risk factors and recurrence of OSCC were studied with logistic regression and a Cox regression model.
The mean age of all 414 patients with OSCC was 58.16 ± 9.92 years; 67.15% were men, 43.24% were cigarette smokers, and 26.09% came from rural areas. In addition, 49.03% of these patients were diagnosed at an early stage. One hundred forty-seven patients developed recurrence of the disease, and the median progression-free survival was 7.3 months (range, 1.1 to 32.5 mo). The recurrence rate was approximately 35.5%.
The study indicated that smoking habit, older age, and living in rural areas were the high-risk epidemiologic factors for OSCC. Smoking habit and late clinical stage were the high-risk factors for the recurrence of OSCC.
分析中国西北地区口腔鳞状细胞癌（OSCC）的流行病学特征及复发因素。
对2007年1月至2008年12月首次就诊于第四军医大学口腔医院的OSCC患者进行调查。采用逻辑回归和Cox回归模型研究OSCC的流行病学危险因素及复发情况。
414例OSCC患者的平均年龄为58.16±9.92岁；男性占67.15%，吸烟者占43.24%，农村地区患者占26.09%。此外，49.03%的患者在早期被诊断。147例患者出现疾病复发，无进展生存期的中位数为7.3个月（范围1.1至32.5个月）。复发率约为35.5%。
该研究表明，吸烟习惯、年龄较大和居住在农村地区是OSCC的高危流行病学因素。吸烟习惯和临床晚期是OSCC复发的高危因素。
