Kutteh W H, Baker V V, Doellgast G J
Department of Obstetrics and Gynecology, University of Alabama Medical Center, Birmingham.
Am J Obstet Gynecol. 1990 Oct;163(4 Pt 1):1301-6. doi: 10.1016/0002-9378(90)90710-o.
Cyst and ascites fluids from patients with ovarian epithelial neoplasms contain immunoglobulins with antitumor activity. Autologous antibodies bound to the cellular membrane fragments obtained from human ovarian neoplastic effusions react with cell-surface antigens on different human ovarian cell lines, surgical specimens of human ovarian adenocarcinoma, and human ovarian tumors grown in athymic Balb/c mice. The antibodies do not react with tissue preparations from normal human ovaries, other nonovarian normal or neoplastic tissues, and nonovarian human cell lines. These studies indicate that these antibodies are capable of complement-mediated lysis of human ovarian tumor cell lines in vitro. Preliminary characterization of the autologous ovarian tumor-associated antigen(s) indicates that it may be composed of three large-molecular-weight proteins of 182,000, 164,000, and 122,000 d.
卵巢上皮性肿瘤患者的囊肿液和腹水含有具有抗肿瘤活性的免疫球蛋白。与从人卵巢肿瘤性积液中获得的细胞膜片段结合的自体抗体，可与不同人卵巢细胞系、人卵巢腺癌手术标本以及在无胸腺Balb/c小鼠体内生长的人卵巢肿瘤上的细胞表面抗原发生反应。这些抗体不与正常人类卵巢、其他非卵巢正常或肿瘤组织以及非卵巢人类细胞系的组织制剂发生反应。这些研究表明，这些抗体在体外能够介导补体对人卵巢肿瘤细胞系的裂解作用。对自体卵巢肿瘤相关抗原的初步表征表明，它可能由三种分子量分别为182,000、164,000和122,000道尔顿的大分子蛋白质组成。
