Division of Natural Product Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India.
Bioorg Med Chem Lett. 2012 Feb 1;22(3):1439-44. doi: 10.1016/j.bmcl.2011.12.015. Epub 2011 Dec 9.
A versatile synthetic route is reported towards the preparation of new analogues for potent neurotrophic agent biaryl-type lignan honokiol. A focused 24-membered library of derivatives containing five different groups at 5'-position of honokiol has been prepared in fair to good overall yields. Compared to the natural product, or to analogues with a short alkyl chain in this position, these new derivatives have lost most of the neurotrophic activity.
现报道一种针对强效神经营养因子联苯型木脂素 honokiol 的新型类似物的通用合成途径。已经以中等至良好的总收率制备了包含 honokiol 5′-位的五个不同基团的 24 元衍生物的重点文库。与天然产物或该位置具有短烷基链的类似物相比，这些新衍生物已失去了大部分神经营养活性。
