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姜朴衍生物的合成及微生物评价作为新型抗菌剂。

Synthesis and microbiological evaluation of honokiol derivatives as new antimicrobial agents.

机构信息

Biospectrum Life Science Institute, SK Ventium 101-701, Gunpo 435-833, Korea.

出版信息

Arch Pharm Res. 2010 Jan;33(1):61-5. doi: 10.1007/s12272-010-2225-7. Epub 2010 Feb 27.

DOI:10.1007/s12272-010-2225-7
PMID:20191344
Abstract

Honokiol, a major phenolic constituent of Magnolia sp., has various pharmacological activities. To improve the solubility and antibacterial activity of honokiol against E. coli and P. aeruginosa, new honokiol-derivatives (honokiol-acetate, honokiol-succinic acid, honokiol-glycerol, honokiol-glycine, honokiol-glucose and honokiol-mannose) were synthesized and their solubility and antimicrobial activities were investigated. Among the tested compounds, honokiol-glycine showed improved water solubility and antibacterial activities against E. coli and P. aeruginosa when compared to honokiol.

摘要

厚朴酚是厚朴属植物的主要酚类成分，具有多种药理活性。为提高厚朴酚对大肠杆菌和铜绿假单胞菌的溶解度和抗菌活性，合成了新的厚朴酚衍生物（厚朴酚乙酸酯、厚朴酚琥珀酸、厚朴酚甘油、厚朴酚甘氨酸、厚朴酚葡萄糖和厚朴酚甘露糖），并研究了它们的溶解度和抗菌活性。在测试的化合物中，与厚朴酚相比，厚朴酚甘氨酸具有更好的水溶性和对大肠杆菌和铜绿假单胞菌的抗菌活性。

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