Paulick R P, Meyers R L, Rudolph C D, Rudolph A M
Cardiovascular Research Institute, University of California, San Francisco 94143.
Am J Obstet Gynecol. 1990 Oct;163(4 Pt 1):1357-63. doi: 10.1016/0002-9378(90)90719-n.
Evidence is accumulating that prostaglandins affect the tone of the ductus venosus. Therefore prostaglandins might alter the distribution of umbilical venous return between the ductus venosus and liver. We have examined the effect of indomethacin and prostaglandin E1 on the vascular resistance of the umbilical-placental circulation, ductus venosus, and liver in 14 chronically instrumented fetal lambs. We found that indomethacin caused a nearly twofold increase in the vascular resistance of both the ductus venosus and liver. Prostaglandin E1, administered 70 minutes after indomethacin at a dose of 0.41 +/- 0.09 (SEM) micrograms/min per kilogram of fetal weight, decreased umbilical-placental blood flow, increased the vascular resistance of the umbilical arteries and placenta, and reversed the elevation of the vascular resistances of the ductus venosus and liver. Because both indomethacin and prostaglandin E1 affected the resistances of the ductus venosus and liver to the same extent, it is unlikely that prostaglandins of the E series mediate the change in distribution of umbilical venous return between the ductus venosus and liver during fetal stress.
越来越多的证据表明，前列腺素会影响静脉导管的张力。因此，前列腺素可能会改变脐静脉回流在静脉导管和肝脏之间的分配。我们研究了吲哚美辛和前列腺素E1对14只长期植入仪器的胎羊脐-胎盘循环、静脉导管和肝脏血管阻力的影响。我们发现，吲哚美辛使静脉导管和肝脏的血管阻力增加了近两倍。在吲哚美辛给药70分钟后，以每千克胎重0.41±0.09（标准误）微克/分钟的剂量给予前列腺素E1，可减少脐-胎盘血流量，增加脐动脉和胎盘的血管阻力，并逆转静脉导管和肝脏血管阻力的升高。由于吲哚美辛和前列腺素E1对静脉导管和肝脏阻力的影响程度相同，因此在胎儿应激期间，E系列前列腺素不太可能介导脐静脉回流在静脉导管和肝脏之间分配的变化。
