Zink J, van Petten G R
Am J Obstet Gynecol. 1980 May 1;137(1):71-7. doi: 10.1016/0002-9378(80)90388-9.
Experiments were conducted with 11 chronically catheterized fetal sheep to determine the effects of norepinephrine on the distribution of umbilical venous blood through the ductus venosus, and within the fetal liver. An intraumbilical infusion of 1.1 microgram/kg/min of norepinephrine increased placental blood flow but did not alter the proportion of this flow that was diverted through the ductus venosus. Under control conditions the umbilical flow to the fetal liver was preferentially distributed to the left side and accounted for 80% of the total hepatic blood flow. Flow through the hepatic artery was negligible. Norepinephrine reduced portal flow but also reduced the asymmetric distribution of hepatic umbilical blood flow by greatly increasing the perfusion of the right side of the fetal liver.
对11只长期插管的胎羊进行了实验，以确定去甲肾上腺素对脐静脉血经静脉导管以及在胎儿肝脏内分布的影响。以1.1微克/千克/分钟的速率脐内输注去甲肾上腺素可增加胎盘血流量，但并未改变经静脉导管分流的血流量比例。在对照条件下，流向胎儿肝脏的脐血流优先分布于左侧，占肝脏总血流量的80%。经肝动脉的血流可忽略不计。去甲肾上腺素减少了门静脉血流，但也通过大幅增加胎儿肝脏右侧的灌注，减少了肝脏脐血流的不对称分布。
