Institute for Research in Immunology and Cancer (IRIC), Department of Pathology and Cell Biology, Université de Montréal, P.O. Box 6128, Station Centre-Ville, Montréal, QC, H3C 3J7, Canada.
Curr Opin Cell Biol. 2012 Feb;24(1):57-63. doi: 10.1016/j.ceb.2011.12.003. Epub 2011 Dec 29.
Protein dynamics generate adaptive cellular architecture. This concept is exemplified by kinetochores, organelles that orchestrate chromosome segregation during mitosis. In this review, we will focus on protein dynamics at kinetochores and discuss how these dynamics impact chromosome motility during mitosis.
蛋白质动力学产生适应性的细胞结构。这一概念的一个例子是动粒,它在有丝分裂过程中协调染色体分离的细胞器。在这篇综述中,我们将重点讨论动粒的蛋白质动力学,并讨论这些动力学如何影响有丝分裂过程中的染色体运动。