Kato Kentaro, Sugi Tatsuki, Iwanaga Tatsuya
Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Parasitol Int. 2012 Jun;61(2):224-34. doi: 10.1016/j.parint.2011.12.002. Epub 2011 Dec 24.
Inhibitors of cellular protein kinases have been reported to inhibit the development of Apicomplexan parasites, suggesting that the functions of protozoan protein kinases are critical for their life cycle. However, the specific roles of these protein kinases cannot be determined using only these inhibitors without molecular analysis, including gene disruption. In this report, we describe the functions of Apicomplexan protein kinases in each parasite life stage and the potential of pre-existing protein kinase inhibitors as Apicomplexan drugs against, mainly, Plasmodium and Toxoplasma.
据报道，细胞蛋白激酶抑制剂可抑制顶复门寄生虫的发育，这表明原生动物蛋白激酶的功能对其生命周期至关重要。然而，仅使用这些抑制剂而不进行包括基因敲除在内的分子分析，就无法确定这些蛋白激酶的具体作用。在本报告中，我们描述了顶复门蛋白激酶在每个寄生虫生命阶段的功能，以及现有蛋白激酶抑制剂作为主要针对疟原虫和弓形虫的顶复门药物的潜力。
