Kato Kentaro
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan.
J Vet Med Sci. 2018 Nov 23;80(11):1702-1706. doi: 10.1292/jvms.18-0344. Epub 2018 Oct 4.
Toxoplasma gondii is a highly prevalent protozoon that can infect all warm-blooded animals, including humans. It is frequently used as an Apicomplexan parasite model in research. In this review, the invasion mechanism of T. gondii is described as a representative Apicomplexan parasite. The invasion machinery of T. gondii consists of the moving junction and the glideosome, which is a specific motor system for Apicomplexan parasites. I provide details about the moving junction, parasite-secreted proteins and host adhesion receptors, the glideosome, and calcium signaling, which generates the power for the gliding mobility of T. gondii. A detailed understanding of parasite invasion can be useful for the development of new effective drugs to inhibit this event and disrupt the Apicomplexan life cycle.
刚地弓形虫是一种高度流行的原生动物，可感染包括人类在内的所有温血动物。在研究中，它经常被用作顶复门寄生虫模型。在这篇综述中，刚地弓形虫的入侵机制被描述为一种典型的顶复门寄生虫。刚地弓形虫的入侵机制由运动连接点和滑行体组成，滑行体是顶复门寄生虫特有的运动系统。我详细介绍了运动连接点、寄生虫分泌蛋白和宿主黏附受体、滑行体以及钙信号传导，钙信号传导为刚地弓形虫的滑行运动提供动力。深入了解寄生虫入侵有助于开发新的有效药物来抑制这一过程并破坏顶复门寄生虫的生命周期。
