Department of Cardiology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Clin Chim Acta. 2012 Apr 11;413(7-8):691-5. doi: 10.1016/j.cca.2011.12.009. Epub 2011 Dec 20.
Cyclophilin A is a secreted molecule that has a physiological and pathological role in cardiovascular diseases. However, limited information is available on the relationship between cyclophilin A concentration and acute coronary syndromes (ACS). We investigated whether cyclophilin A concentration is related to the stability of coronary atherosclerotic plaque in patients with ACS.
This study included normal controls (n=50), patients with stable angina (SA) (n=60) and patients with ACS, including unstable angina (UA) (n=60) and acute myocardial infarction (AMI) (n=90). Serum soluble cyclophilin A, matrix metalloproteinase 9 (MMP-9), MMP-3 and C-reactive protein concentrations (CRP) were measured. All coronary stenosis were assessed by angiographic coronary stenosis morphology.
Serum cyclophilin A concentration in ACS (UA and AMI ) subjects were significantly higher than those in patients with SA and controls (p<0.05). Serum cyclophilin A correlated positively with serum MMP-3 and MMP-9 and CRP in ACS patients(r(1)=0.69, r(2)=0.52, r(3)=0.49 p<0.0001), but not in control. Furthermore, the increased cyclophilin A concentrations was associated with the number of complex coronary stenoses (r(1)=0.63, p<0.0001), but not smooth lesions or stenosis severity, in coronary artery disease patients. Logistic regression analysis also demonstrated that serum cyclophilin A concentration was an independent predictor factor for ACS( OR, 2.721, 95% CI 1.563-4.042, p=0.001).
Patients with ACS showed that increased concentrations of cyclophilin A may be a valuable marker for predicting the severity of ACS.
亲环素 A 是一种分泌型分子，在心血管疾病中具有生理和病理作用。然而，关于亲环素 A 浓度与急性冠状动脉综合征（ACS）之间的关系，信息有限。我们研究了亲环素 A 浓度是否与 ACS 患者冠状动脉粥样硬化斑块的稳定性有关。
本研究纳入了正常对照组（n=50）、稳定性心绞痛（SA）患者（n=60）和 ACS 患者，包括不稳定型心绞痛（UA）（n=60）和急性心肌梗死（AMI）（n=90）。测量血清可溶性亲环素 A、基质金属蛋白酶 9（MMP-9）、MMP-3 和 C 反应蛋白（CRP）浓度。所有冠状动脉狭窄均通过血管造影冠状动脉狭窄形态进行评估。
ACS（UA 和 AMI）患者的血清亲环素 A 浓度明显高于 SA 患者和对照组（p<0.05）。ACS 患者的血清亲环素 A 与血清 MMP-3 和 MMP-9 以及 CRP 呈正相关（r(1)=0.69，r(2)=0.52，r(3)=0.49 p<0.0001），但在对照组中没有相关性。此外，在冠状动脉疾病患者中，亲环素 A 浓度的升高与复杂冠状动脉狭窄的数量相关（r(1)=0.63，p<0.0001），而与平滑病变或狭窄严重程度无关。Logistic 回归分析还表明，血清亲环素 A 浓度是 ACS 的独立预测因子（OR，2.721，95% CI 1.563-4.042，p=0.001）。
ACS 患者的研究表明，亲环素 A 浓度的升高可能是预测 ACS 严重程度的有价值标志物。
