Campbell Nancy H, Neidle Stephen
The School of Pharmacy, University of London, London, WC1N 1AX, UK.
Met Ions Life Sci. 2012;10:119-34. doi: 10.1007/978-94-007-2172-2_4.
Metal ions stabilize quadruplex nucleic acids by coordinating the O6 guanine atoms from G-quartets. These quartets form the basic motif of quadruplex structures. This article systematically surveys the available crystallographic data on native quadruplexes, their ligand complexes and (in one instance) a protein complex. Three categories of quadruplex are examined, tetramolecular, bimolecular, and intramolecular: all are formed by telomeric nucleic acid sequences from human or ciliate organisms.
金属离子通过与G-四联体中的O6鸟嘌呤原子配位来稳定四链体核酸。这些四联体构成了四链体结构的基本基序。本文系统地综述了关于天然四链体、其配体复合物以及（在一个实例中）蛋白质复合物的现有晶体学数据。研究了三类四链体，即四分子、双分子和分子内四链体：它们均由人类或纤毛虫生物体的端粒核酸序列形成。
