Cummings J F, de Lahunta A, Timoney J F
Acta Neuropathol. 1979 Apr 12;46(1-2):17-24. doi: 10.1007/BF00684799.
Four cases of neuritis of the cauda equina (NCE) were studied by light and electron microscopy. Examination of sacral intradural rootlets revealed inflammatory cell infiltrates and an array of myelinated fiber changes which included myelin stripping by invading mononuclear cells and macrophages, as well as splitting and vesiculation of myelin lamellae without obvious participation by leukocytes. More distally in the extradural roots, there was marked granulomatous inflammation, and demyelinative changes were overshadowed by widespread evidence of irreversible axon damage. In all cases, unusual crystalline inclusions appeared in the endoneurium and sheaths of the rootlets and fascicles. The changes in NCE were compared and contrasted with those observed in acute and chronic inflammatory demyelinative neuropathies.
对4例马尾神经炎（NCE）进行了光镜和电镜研究。对骶段硬膜内神经根的检查显示有炎性细胞浸润以及一系列有髓纤维改变，包括单核细胞和巨噬细胞侵入导致的髓鞘剥脱，以及髓鞘板层的分裂和形成小泡，且无白细胞明显参与。在硬膜外神经根更远端处，有明显的肉芽肿性炎症，不可逆轴突损伤的广泛证据使脱髓鞘改变相形见绌。在所有病例中，神经内膜和神经根束及束膜中均出现异常结晶包涵体。将NCE中的改变与急性和慢性炎性脱髓鞘性神经病中观察到的改变进行了比较和对比。
