Wakahashi Senn, Sudo Tamotsu, Nakagawa Eriko, Ueno Sayaka, Muraji Miho, Kanayama Seiji, Itami Hiroe, Kawakami Fumi, Yamada Takashi, Yamaguchi Satoshi, Fujiwara Kiyoshi, Nishikawa Hironobu, Nishimura Ryuichiro, Ohbayashi Chiho
1. Department of Gynecologic Oncology, Hyogo Cancer Center, 13-70 Kita-Oji, Akashi, Hyogo 673-8558, Japan.
J Cancer. 2012;3:14-8. doi: 10.7150/jca.3.14. Epub 2011 Dec 1.
A choriocarcinoma component with a malignant tumor is relatively rare. We present a case of an 85-year-old woman with mixed carcinoma, which was endometrioid adenocarcinoma with squamous differentiation, choriocarcinoma and a disseminated peritoneal nodule, which was papillary serous adenocarcinoma. The patient received surgery and conservative treatment. Twenty weeks after surgery, a recurring tumor appeared at the Douglas pouch. Histology showed that the recurring tumor was poorly differentiated carcinoma that was very different from the primary tumor. This case represents an unusual uterine corpus cancer with high-grade transformation with serous and choriocarcinomatous differentiation. This case also demonstrates the capacity of tumor cells to differentiate into divergent elements.
伴有恶性肿瘤的绒毛膜癌成分相对罕见。我们报告一例85岁女性的混合性癌病例，其为具有鳞状分化的子宫内膜样腺癌、绒毛膜癌以及一个播散性腹膜结节，该结节为乳头状浆液性腺癌。患者接受了手术及保守治疗。术后20周，Douglas窝出现复发性肿瘤。组织学检查显示，复发性肿瘤为低分化癌，与原发肿瘤差异很大。该病例代表了一种具有浆液性和绒毛膜癌分化的高级别转化的不寻常子宫体癌。该病例还证明了肿瘤细胞分化为不同成分的能力。
