Department of Urology, National Hospital Organization Osaka National Hospital, Osaka, Japan.
Int J Urol. 2012 Apr;19(4):370-2. doi: 10.1111/j.1442-2042.2011.02944.x. Epub 2011 Dec 29.
We describe an extremely rare case of poorly differentiated neuroendocrine carcinoma arising from the seminal vesicle. A 67-year-old man presented with a left humeral bone tumor resulting in a pathological fracture. Positron emission tomography scan disclosed a large pelvic tumor mimicking prostatic cancer invading into the seminal vesicle. Laboratory data showed an elevation of neuron-specific enolase, despite the normal prostate-specific antigen. Transrectal needle biopsy showed a poorly differentiated carcinoma of the right seminal vesicle and the metastasis of the pelvic lymph node. Immunohistochemical results were compatible with the features of neuroendocrine carcinoma; synaptophysin, chromogranin A and CD 56 were positive. The previously biopsied bone tumor was finally diagnosed as a metastasis. A systemic chemotherapy using etoposide and cisplatin failed. The patient died of cancer one-and-a-half years later.
我们描述了一例极为罕见的源自精囊的低分化神经内分泌癌。一名 67 岁男性因左肱骨骨肿瘤导致病理性骨折就诊。正电子发射断层扫描显示一个大型盆腔肿瘤，类似于侵犯精囊的前列腺癌。实验室数据显示神经元特异性烯醇化酶升高，尽管前列腺特异性抗原正常。经直肠针吸活检显示右侧精囊的低分化癌和盆腔淋巴结转移。免疫组织化学结果符合神经内分泌癌的特征；突触素、嗜铬粒蛋白 A 和 CD56 阳性。之前活检的骨肿瘤最终被诊断为转移。使用依托泊苷和顺铂的全身化疗失败。患者在一年半后死于癌症。
