School of Medicine, Tzu Chi University, Hualien, Taiwan.
Clin Transplant. 2012 Mar-Apr;26(2):E105-10. doi: 10.1111/j.1399-0012.2011.01575.x. Epub 2011 Dec 29.
Our aim was to evaluate the relationship between bone mineral density (BMD) and fasting serum long-acting natriuretic peptide (LANP) concentration in renal transplant recipients.
Fasting blood samples were obtained from 65 renal transplant recipients. BMD was measured using dual energy X-ray absorptiometry in lumbar vertebrae (L2-L4). Serum LANP levels were measured using a commercial enzyme immunoassay kit.
Six patients (9.2%) had osteoporosis and 28 patients (43.1%) had osteopenia in renal transplant recipients. Increased serum LANP (p<0.001) was significantly correlated with low lumbar T-score cut-off points between groups (normal, osteopenia, and osteoporosis) in renal transplant recipients. Female patients had lower lumbar BMD than male renal transplant recipients (p=0.027). Univariate linear regression analysis indicated that lumbar BMD were positively correlated with height (p=0.038), body weight (p=0.003), and body mass index (BMI; p=0.019), whereas negatively correlated with LANP (p=0.004) among the renal transplant recipients. Multivariate forward stepwise linear regression analysis of the significant variables revealed that body weight (R(2) change=0.132; p=0.006) and LANP (R(2) change=0.093; p=0.008) were the independent predictors of lumbar BMD values in the renal transplant recipients.
Serum LANP concentration correlates negatively with lumbar BMD values in renal transplant recipients.
评估肾移植受者骨密度（BMD）与空腹血清长效利钠肽（LANP）浓度之间的关系。
从 65 名肾移植受者中采集空腹血样。使用双能 X 射线吸收法在腰椎（L2-L4）测量 BMD。使用商业酶免疫测定试剂盒测量血清 LANP 水平。
6 名患者（9.2%）患有骨质疏松症，28 名患者（43.1%）患有骨质疏松症。血清 LANP 升高（p<0.001）与肾移植受者腰椎 T 评分截断点之间的低分组（正常、骨质疏松症和骨质疏松症）显著相关。女性患者的腰椎 BMD 低于男性肾移植受者（p=0.027）。单因素线性回归分析表明，腰椎 BMD 与身高（p=0.038）、体重（p=0.003）和体重指数（BMI；p=0.019）呈正相关，与 LANP（p=0.004）呈负相关。肾移植受者中，对显著变量进行多元逐步线性回归分析显示，体重（R²变化=0.132；p=0.006）和 LANP（R²变化=0.093；p=0.008）是腰椎 BMD 值的独立预测因子。
血清 LANP 浓度与肾移植受者的腰椎 BMD 值呈负相关。
