Center for Research on Occupational and Environmental Toxicology, Oregon Health & Science University, Portland, Oregon, USA.
Ann N Y Acad Sci. 2011 Dec;1243:47-53. doi: 10.1111/j.1749-6632.2011.06303.x.
Stearoyl-CoA desaturase 1 (SCD1) is an essential lipogenic enzyme that has been shown to play an intrinsic role in the development of obesity and related conditions, such as insulin resistance. Through the generation of various mouse models of SCD1 deficiency, we have come to understand that SCD1 plays a role, directly or indirectly, in diverse metabolic processes, including lipogenesis, fatty acid oxidation, insulin signaling, thermogenesis, and inflammation. This review will address recent advances in our understanding of this key regulator of cellular metabolic processes, including the role of SCD1 in maintaining skin barrier integrity and the role of skin SCD1 in the metabolic phenotype elicited by global SCD1 deficiency.
硬脂酰辅酶 A 去饱和酶 1（SCD1）是一种必需的脂肪生成酶，已被证明在肥胖和相关疾病（如胰岛素抵抗）的发展中具有内在作用。通过生成各种 SCD1 缺乏的小鼠模型，我们已经了解到 SCD1 直接或间接地在多种代谢过程中发挥作用，包括脂肪生成、脂肪酸氧化、胰岛素信号转导、产热和炎症。本综述将讨论我们对这一细胞代谢过程关键调节因子的理解的最新进展，包括 SCD1 在维持皮肤屏障完整性中的作用以及皮肤 SCD1 在由全身 SCD1 缺乏引起的代谢表型中的作用。
