疾病的动物模型是否有助于或阻碍了药物发现过程？

Have animal models of disease helped or hindered the drug discovery process?

机构信息

OI Pharma Partners Ltd. Weston, Herts, United Kingdom.

出版信息

Ann N Y Acad Sci. 2011 Dec;1245:1-2. doi: 10.1111/j.1749-6632.2011.06375.x.

DOI:10.1111/j.1749-6632.2011.06375.x

PMID:22211963

Abstract

Animal models have played an important role in target validation, screening of compounds for efficacy and optimization of pharmacokinetic properties and toxicological testing. However, new paradigms for drug discovery and development will require a greater emphasis on animal models of mechanism.

摘要

动物模型在靶标验证、化合物的疗效筛选以及药代动力学性质的优化和毒理学测试中发挥了重要作用。然而，新药发现和开发的新模式将需要更加重视机制的动物模型。