定量 T2' 成像在临床孤立综合征患者中的应用。
Quantitative T2' imaging in patients with clinically isolated syndrome.
机构信息
Department of Neurology, Institute for Neuroimmunology and Clinical Multiple Sclerosis Research (inims), University Medical Center, Hamburg, DE, Germany.
出版信息
Acta Neurol Scand. 2012 Nov;126(5):357-63. doi: 10.1111/j.1600-0404.2011.01635.x. Epub 2012 Jan 3.
OBJECTIVE
The T2' imaging has been shown to be sensitive to oxygen saturation changes in normal appearing white and grey matter (NAWM, NAGM) in patients with relapsing-remitting multiple sclerosis (RRMS). We aimed to explore the presence and extent of T2' changes in patients with a clinically isolated syndrome (CIS) and a possible association of T2' with conventional magnetic resonance imaging and clinical outcomes.
MATERIAL AND METHODS
Quantitative T2- and T2*-weighted images were acquired in 32 treatment-naive patients with a CIS within 3 months of presentation and 15 age-matched healthy controls (HC). Quantitative T2' values were determined in six regions of interest (ROIs).
RESULTS
The T2' values in CIS did not differ significantly from those in HC. Among patients, T2' values correlated positively with the T2 lesion volume (T2LV, r = 0.34, P < 0.05). T2' values of the frontal NAWM correlated with the T2LV (r = 0.35, P < 0.05) and T2 lesion count (r = 0.4, P = 0.02).
CONCLUSION
As opposed to RRMS, patients with CIS did not show T2' alterations compared to HC. However, the association between the T2LV and higher T2' values suggests that T2' reflects disease evolution. In CIS metabolic changes might be masked by compensatory mechanisms and become overt when disease progresses as has been shown for RRMS patients.
目的
T2' 成像已被证明对复发缓解型多发性硬化症（RRMS）患者正常外观的白质和灰质（NAWM、NAGM）中的氧饱和度变化敏感。我们旨在探讨临床孤立综合征（CIS）患者中 T2' 变化的存在和程度，以及 T2' 与常规磁共振成像和临床结果的可能关联。
材料和方法
在发病后 3 个月内的 32 例未经治疗的 CIS 患者和 15 名年龄匹配的健康对照者（HC）中采集定量 T2-和 T2*-加权图像。在 6 个感兴趣区域（ROI）中确定定量 T2' 值。
结果
CIS 的 T2' 值与 HC 相比无显著差异。在患者中，T2' 值与 T2 病变体积（T2LV）呈正相关（r=0.34，P<0.05）。额 NAWM 的 T2' 值与 T2LV（r=0.35，P<0.05）和 T2 病变计数（r=0.4，P=0.02）呈正相关。
结论
与 RRMS 相反，与 HC 相比，CIS 患者未显示 T2' 改变。然而，T2LV 与更高的 T2' 值之间的关联表明 T2' 反映了疾病的演变。在 CIS 中，代谢变化可能被代偿机制所掩盖，并且当疾病进展时会变得明显，正如 RRMS 患者所显示的那样。
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