Holst B, Siemonsen S, Finsterbusch J, Bester M, Schippling S, Martin R, Fiehler J
Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Mult Scler. 2009 Jun;15(6):701-7. doi: 10.1177/1352458509103713.
T2'-Magnetic resonance imaging (MRI) allows estimation of oxygen metabolism in normal appearing white and gray matter (NAWM and NAGM) and is sensitive to local iron deposition. We hypothesized that T2' imaging is feasible in routine use and reveals differences between MS patients and healthy subjects.
T2- and T2*-weighted images were acquired in 23 MS patients (Mean age: 36.8, range: 23-58 years) and 23 age-matched healthy subjects. Quantitative T2- and T2*-values were determined in six regions of interest (ROIs).
The T2' values in thalamus and caudate nucleus were significantly lower in MS patients than in healthy subjects (139 ms vs 157 ms, P < 0.001 and 97 ms vs 115 ms, P < 0.01). The NAWM in the frontal lobe revealed significant higher T2' values than in healthy subjects (217 ms vs 170 ms, P < 0.001). The subcortical NAWM revealed significant lower T2' values than in healthy subjects (174 ms vs 187 ms, P < 0.028).
T2' values differed significantly between MS patients and healthy subjects. The reduced T2' values in the basal ganglia are presumably related to higher iron concentration whereas the increased T2' in frontal NAWM most probably reflects reduced tissue metabolism. T2' imaging is feasible for routine-use and promising for monitoring therapy effects.
T2'磁共振成像（MRI）可用于评估正常外观的白质和灰质（NAWM和NAGM）中的氧代谢情况，并且对局部铁沉积敏感。我们推测T2'成像在常规应用中是可行的，并且能够揭示多发性硬化症（MS）患者与健康受试者之间的差异。
对23例MS患者（平均年龄：36.8岁，范围：23 - 58岁）和23例年龄匹配的健康受试者进行了T2加权和T2加权成像。在六个感兴趣区域（ROI）测定了定量T2和T2值。
MS患者丘脑和尾状核的T2'值显著低于健康受试者（分别为139 ms对157 ms，P < 0.001；97 ms对115 ms，P < 0.01）。额叶的NAWM显示T2'值显著高于健康受试者（217 ms对170 ms，P < 0.001）。皮质下NAWM的T2'值显著低于健康受试者（174 ms对187 ms，P < 0.028）。
MS患者与健康受试者的T2'值存在显著差异。基底节区T2'值降低可能与铁浓度升高有关，而额叶NAWM中T2'值升高很可能反映了组织代谢降低。T2'成像在常规应用中是可行的，并且在监测治疗效果方面具有前景。
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