植物固醇添加剂可增强雄性日本鹌鹑（Coturnix coturnix japonica）对 ACTH 的肾上腺反应。

Phytosterol additive boosts adrenal response to ACTH in male Japanese quail (Coturnix coturnix japonica).

机构信息

Laboratory of Animal Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, People's Republic of China.

出版信息

Endocrine. 2012 Apr;41(2):338-41. doi: 10.1007/s12020-011-9590-y. Epub 2012 Jan 3.

DOI:10.1007/s12020-011-9590-y

PMID:22212440

Abstract

To investigate the adrenal effect of a phytosterol (PS) additive, 80 male Japanese quail were divided into four sub-groups and fed 0, 40, 400, and 4,000 ppm of PS, respectively, for 21 days. Subsequently, 50% of the birds from each dosage group were subjected to a 6-day adrenal function test, whereby they were injected with long-lasting adrenocorticotropin (ACTH). The remaining quail in each PS dosage group were raised under normal conditions. The groups receiving 400 and 4000 ppm PS exhibited decreased serum levels of LDL-cholesterol with and without ACTH stimulation (P < 0.01). No amount of dose of PS changed serum corticosterone (CORT) under normal conditions (P > 0.05). Enhancement of CORT was observed on the 2nd and the 6th days of the ACTH challenge in birds receiving 400 ppm (P < 0.05). Average ACTH-induced CORT levels in the 400 ppm group were higher than in the 0 ppm group (P < 0.01). Our results demonstrated that PS can boost ACTH-induced CORT levels in male Japanese quail.

摘要

为了研究植物固醇（PS）添加剂对肾上腺的影响，将 80 只雄性日本鹌鹑分为四组，分别喂食 0、40、400 和 4000ppm 的 PS，持续 21 天。随后，每组中的 50%的鹌鹑接受为期 6 天的肾上腺功能测试，通过注射长效促肾上腺皮质激素（ACTH）。每个 PS 剂量组的其余鹌鹑在正常条件下饲养。接受 400 和 4000ppm PS 的组在有和没有 ACTH 刺激的情况下，血清 LDL-胆固醇水平降低（P<0.01）。在正常条件下，任何剂量的 PS 都不会改变血清皮质酮（CORT）水平（P>0.05）。在接受 400ppm PS 的鸟类中，在 ACTH 挑战的第 2 天和第 6 天观察到 CORT 增强（P<0.05）。在 400ppm 组中，平均 ACTH 诱导的 CORT 水平高于 0ppm 组（P<0.01）。我们的结果表明，PS 可以提高雄性日本鹌鹑中 ACTH 诱导的 CORT 水平。