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丙型肝炎治疗的障碍。

Barriers to hepatitis C treatment.

机构信息

Division of Gastroenterology and Hepatology, UNC Liver Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7584, USA.

出版信息

Liver Int. 2012 Feb;32 Suppl 1(0 1):151-6. doi: 10.1111/j.1478-3231.2011.02706.x.

DOI:10.1111/j.1478-3231.2011.02706.x
PMID:22212587
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3955982/
Abstract

Despite the availability of highly effective therapy for hepatitis C virus (HCV) infection, few patients receive treatment. Barriers arising at multiple levels, from diagnosis to specialist referral, may impede the delivery of hepatitis C care. At the patient level, lack of awareness, fear of side effects, poor adherence and comorbid conditions may prevent treatment. For providers, limited knowledge, lack of availability and communication difficulties may be problematic. At the government and payer level, a lack of promotion, surveillance and funding may interfere. Each of these barriers needs to be addressed if wider implementation of antiviral therapy is to be achieved.

摘要

尽管已有针对丙型肝炎病毒 (HCV) 感染的高效疗法,但仍有少数患者接受治疗。从诊断到专科转诊,多个层面上存在的障碍可能会阻碍丙型肝炎治疗的开展。在患者层面,缺乏意识、对副作用的恐惧、治疗依从性差和合并症等因素可能会导致治疗受阻。对于医疗服务提供者来说,知识有限、资源缺乏和沟通困难等问题也会带来挑战。在政府和支付方层面,宣传、监测和资金不足等问题也可能会造成阻碍。如果要更广泛地实施抗病毒治疗,就需要解决这些障碍中的每一个。

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A global view of hepatitis C: physician knowledge, opinions, and perceived barriers to care.全球丙型肝炎概况:医生的知识、意见和对护理的认知障碍。
Hepatology. 2013 Apr;57(4):1325-32. doi: 10.1002/hep.26246.
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An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases.1型慢性丙型肝炎病毒感染治疗的最新进展:美国肝病研究协会2011年实践指南
Hepatology. 2011 Oct;54(4):1433-44. doi: 10.1002/hep.24641. Epub 2011 Sep 26.
3
The state of hepatitis B and C in Europe: report from the hepatitis B and C summit conference*.
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Healthc Manage Forum. 2025 Jun 23;38(5):8404704251350064. doi: 10.1177/08404704251350064.
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J Health Care Poor Underserved. 2025;36(1):257-283. doi: 10.1353/hpu.2025.a951596.
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Results from a retrospective case finding and re-engagement exercise for people previously diagnosed with hepatitis C virus to increase uptake of directly acting antiviral treatment.一项回顾性病例发现和重新参与活动的结果,旨在提高以前诊断为丙型肝炎病毒的人的直接抗病毒治疗的接受率。
BMC Public Health. 2024 Sep 6;24(1):2427. doi: 10.1186/s12889-024-19919-3.
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Can Liver J. 2022 Nov 7;5(4):513-529. doi: 10.3138/canlivj-2022-0018. eCollection 2022 Nov.
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Hepatology. 2010 Mar;51(3):729-33. doi: 10.1002/hep.23561.
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Liver Int. 2010 Feb;30(2):240-50. doi: 10.1111/j.1478-3231.2009.02156.x. Epub 2009 Nov 4.