Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.
Oncology. 2011;81 Suppl 1:61-5. doi: 10.1159/000333263. Epub 2011 Dec 22.
The highly sensitive Lens culinaris agglutinin-reactive α-fetoprotein (hs-AFP-L3), measured using a newly developed method involving microfluidics-based separation technology, was evaluated as a new tool for the management of hepatocellular carcinoma (HCC) in clinical practice.
The sensitivity and specificity of hs-AFP-L3 for the diagnosis of HCC and its ability to predict the outcome of patients with HCC were analyzed based on reported studies.
Compared to AFP-L3 measured using conventional methods, the sensitivity of hs-AFP-L3 was markedly higher and the specificity was comparable. In all studies, multivariate analysis found that elevation of hs-AFP-L3 was an independent factor that affected patient survival.
The use of hs-AFP-L3 improves the true positive rate of patients with HCC at diagnosis, maintaining the high specificity of AFP-L3 and its indicative value for poor prognosis. The utility of this tumor marker for prediction of the development of HCC in high-risk patients under surveillance needs to be investigated.
使用新开发的基于微流控分离技术的方法测量高度敏感的扁豆凝集素反应性甲胎蛋白（hs-AFP-L3），评估其作为肝细胞癌（HCC）临床管理的新工具。
根据已发表的研究，分析 hs-AFP-L3 对 HCC 诊断的敏感性和特异性及其预测 HCC 患者预后的能力。
与使用常规方法测量的 AFP-L3 相比，hs-AFP-L3 的敏感性明显更高，特异性相当。在所有研究中，多变量分析发现 hs-AFP-L3 升高是影响患者生存的独立因素。
hs-AFP-L3 的使用提高了 HCC 患者诊断时的真阳性率，同时保持了 AFP-L3 的高特异性及其对预后不良的指示价值。需要研究该肿瘤标志物在监测高危患者 HCC 发展中的预测作用。
