Karolinska Institutet, Stockholm, Sweden.
Eur J Immunol. 2012 Jan;42(1):45-7. doi: 10.1002/eji.201142048.
The dramatic increase in the amount of research data being produced necessarily leads to higher demands on statistical thresholds and on experimental planning. This is to avoid positive selection of multiple tested data. Here we would like to highlight the need for including littermate controls in animal experiments, in particular when genetically modified strains are analysed for quantitative phenotypes. Thus, this suggestion will have impact on most immunological experiments performed today.
研究数据量的急剧增加必然导致对统计阈值和实验计划的更高要求。这是为了避免对多个测试数据进行正向选择。在这里，我们想强调在动物实验中包括同窝对照的必要性，特别是在分析遗传修饰品系的定量表型时。因此，这一建议将对当今大多数进行的免疫学实验产生影响。
