Bruschi Fabrizio, Chiumiento Lorena
Department of Experimental Pathology, Università di Pisa, Via Roma, 55 56122 Pisa, Italy.
Endocr Metab Immune Disord Drug Targets. 2012 Mar;12(1):4-15. doi: 10.2174/187153012799279081.
This review describes different aspects of the host immune response to Trichinella. The role of antibodies, T cells, mast cells, eosinophils and neutrophils in immune reaction to this nematode is considered, in the light of the recent data derived from experimental models, both in in vivo and in vitro. The knowledge of immune response mechanisms against Trichinella is fundamental to understand how the parasite can escape such mechanisms. The principal evasion mechanisms of host immune response occurring in trichinellosis are described, some of which are shared by other parasites, some others are peculiar of this parasite, but particular attention is focused on immunomodulation and the possibilities to exploit this parasite ability to verify the effects on immuno-mediated diseases. In conclusion, some considerations on the actual ability to escape the host immune response by the parasite are discussed, taking into account the recent data that shows that the parasite might rather drive immune system of the host towards a less dangerous response.
本综述描述了宿主对旋毛虫免疫反应的不同方面。根据最近从体内和体外实验模型获得的数据，探讨了抗体、T细胞、肥大细胞、嗜酸性粒细胞和中性粒细胞在针对这种线虫的免疫反应中的作用。了解针对旋毛虫的免疫反应机制对于理解该寄生虫如何逃避这些机制至关重要。本文描述了旋毛虫病中宿主免疫反应的主要逃避机制，其中一些与其他寄生虫相同，另一些则是该寄生虫特有的，但特别关注免疫调节以及利用该寄生虫能力来验证其对免疫介导疾病影响的可能性。总之，考虑到最近的数据表明该寄生虫可能会使宿主免疫系统朝着危险性较小的反应方向发展，本文讨论了有关该寄生虫实际逃避宿主免疫反应能力的一些观点。
