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乳腺癌中难以捉摸的核外雌激素受体。

Elusive extranuclear estrogen receptors in breast cancer.

机构信息

Division of Endocrinology, Department of Medicine, University of California, Irvine, Irvine, California, USA.

出版信息

Clin Cancer Res. 2012 Jan 1;18(1):6-8. doi: 10.1158/1078-0432.CCR-11-2547.

DOI:10.1158/1078-0432.CCR-11-2547
PMID:22215901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3257555/
Abstract

Estrogen receptors at the plasma membrane and cytoplasm have been difficult to detect in breast cancer specimens. New imaging approaches are needed to determine the percentage of cancers expressing extranuclear estrogen receptors and their impact on cancer biology and treatment.

摘要

在乳腺癌标本中,很难检测到质膜和细胞质中的雌激素受体。需要新的成像方法来确定表达核外雌激素受体的癌症的百分比,以及它们对癌症生物学和治疗的影响。

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Elusive extranuclear estrogen receptors in breast cancer.乳腺癌中难以捉摸的核外雌激素受体。
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本文引用的文献

1
Cytoplasmic estrogen receptor in breast cancer.乳腺癌细胞质雌激素受体。
Clin Cancer Res. 2012 Jan 1;18(1):118-26. doi: 10.1158/1078-0432.CCR-11-1236. Epub 2011 Oct 6.
2
Diffraction-unlimited all-optical imaging and writing with a photochromic GFP.利用光致变色 GFP 实现无衍射极限的全光学成象和写入。
Nature. 2011 Sep 11;478(7368):204-8. doi: 10.1038/nature10497.
3
Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice.非核雌激素受体α信号促进心血管保护,但不促进小鼠子宫或乳腺癌生长。
J Clin Invest. 2010 Jul;120(7):2319-30. doi: 10.1172/JCI38291. Epub 2010 Jun 23.
4
Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membrane.热休克蛋白 27 对于性激素受体向质膜的运输和在质膜上的功能发挥是必需的。
Mol Cell Biol. 2010 Jul;30(13):3249-61. doi: 10.1128/MCB.01354-09. Epub 2010 May 3.
5
Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice.乳腺上皮中雌激素受体α的表达是小鼠导管和腺泡形态发生所必需的。
Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14718-23. doi: 10.1073/pnas.0706933104. Epub 2007 Sep 4.
6
Estrogen receptors outside the nucleus in breast cancer.乳腺癌细胞核外的雌激素受体
Breast Cancer Res Treat. 2008 Apr;108(3):351-61. doi: 10.1007/s10549-007-9618-4. Epub 2007 Jun 26.
7
Nature of functional estrogen receptors at the plasma membrane.质膜上功能性雌激素受体的性质。
Mol Endocrinol. 2006 Sep;20(9):1996-2009. doi: 10.1210/me.2005-0525. Epub 2006 Apr 27.
8
Stress and the general adaptation syndrome.压力与一般适应综合征。
Br Med J. 1950 Jun 17;1(4667):1383-92. doi: 10.1136/bmj.1.4667.1383.
9
Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases.孕酮受体含有一个富含脯氨酸的基序,该基序直接与SH3结构域相互作用并激活c-Src家族酪氨酸激酶。
Mol Cell. 2001 Aug;8(2):269-80. doi: 10.1016/s1097-2765(01)00304-5.
10
Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells.细胞膜和核雌激素受体(ERs)源自单一转录本:对中国仓鼠卵巢细胞中表达的ERα和ERβ的研究。
Mol Endocrinol. 1999 Feb;13(2):307-19. doi: 10.1210/mend.13.2.0239.