Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA.
J Dent Res. 2012 Jun;91(6):528-35. doi: 10.1177/0022034511434055. Epub 2012 Jan 4.
The tongue exerts crucial functions in our daily life. However, we know very little about the regulatory mechanisms of mammalian tongue development. In this review, we summarize recent findings of the molecular and cellular mechanisms that control tissue-tissue interactions during tongue morphogenesis. Specifically, cranial neural crest cells (CNCC) lead the initiation of tongue bud formation and contribute to the interstitial connective tissue, which ultimately compartmentalizes tongue muscles and serves as their attachments. Occipital somite-derived cells migrate into the tongue primordium and give rise to muscle cells in the tongue. The intimate relationship between CNCC- and mesoderm-derived cells, as well as growth and transcription factors that have been shown to be crucial for tongue myogenesis, clearly indicate that tissue-tissue interactions play an important role in regulating tongue morphogenesis.
舌头在我们的日常生活中发挥着至关重要的作用。然而，我们对哺乳动物舌头发育的调控机制知之甚少。在这篇综述中，我们总结了控制舌头形态发生过程中组织-组织相互作用的分子和细胞机制的最新发现。具体来说，颅神经嵴细胞（CNCC）启动了舌芽的形成，并有助于间质结缔组织的形成，最终将舌肌分隔开，并作为其附着点。来自枕骨体节的细胞迁移到舌原基中，并在舌中产生肌肉细胞。CNCC 和中胚层来源的细胞之间的密切关系，以及已经证明对舌肌发生至关重要的生长和转录因子，清楚地表明组织-组织相互作用在调节舌头形态发生中起着重要作用。
