体节发生：从体节到骨骼肌。

Somitogenesis: From somite to skeletal muscle.

作者信息

Musumeci Giuseppe, Castrogiovanni Paola, Coleman Raymond, Szychlinska Marta Anna, Salvatorelli Lucia, Parenti Rosalba, Magro Gaetano, Imbesi Rosa

机构信息

Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Catania, Italy.

出版信息

Acta Histochem. 2015 May-Jun;117(4-5):313-28. doi: 10.1016/j.acthis.2015.02.011. Epub 2015 Apr 4.

DOI:10.1016/j.acthis.2015.02.011

PMID:25850375

Abstract

Myogenesis is controlled by an elaborate system of extrinsic and intrinsic regulatory mechanisms in all development stages. The aim of this review is to provide an overview of the different stages of myogenesis and muscle differentiation in mammals, starting from somitogenesis and analysis of the different portions that constitute the mature somite. Particular attention was paid to regulatory genes, in addition to mesodermal stem cells, which represent the earliest elements of myogenesis. Finally, the crucial role of growth factors, molecules of vital importance in contractile regulation, hormones and their function in skeletal muscle differentiation, growth and metabolism, and the role played by central nervous system, are discussed.

摘要

在所有发育阶段，肌生成均由一套复杂的外在和内在调节机制系统控制。本综述的目的是概述哺乳动物肌生成和肌肉分化的不同阶段，从体节发生开始，并分析构成成熟体节的不同部分。除了中胚层干细胞（肌生成的最早元素）之外，还特别关注了调节基因。最后，讨论了生长因子（在收缩调节中至关重要的分子）、激素及其在骨骼肌分化、生长和代谢中的功能，以及中枢神经系统所起的作用。