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一例肌萎缩侧索硬化合并华氏巨球蛋白血症及抗MAG丙种球蛋白病的尸检病例

An Autopsy Case of Amyotrophic Lateral Sclerosis with Waldenström Macroglobulinemia and Anti-MAG Gammopathy.

作者信息

Jurici Snejana, Laquerrière Annie, Bedat-Millet Anne-Laure, Jardin Fabrice, Musset Lucile, Vallat Jean-Michel, Hannequin Didier, Martinaud Olivier

机构信息

Department of Neurology, Faculty of Medicine and Pharmacy, Rouen.

出版信息

Case Rep Neurol. 2011 Sep;3(3):294-300. doi: 10.1159/000335004. Epub 2011 Dec 5.

DOI:10.1159/000335004
PMID:22220157
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3250649/
Abstract

We report the case of a 71-year-old woman with typical signs of bulbar amyotrophic lateral sclerosis (ALS) associated with immunoglobulin M (IgM) monoclonal gammopathy and anti-MAG (myelin-associated glycoprotein) antibodies. This unusual association between ALS and anti-MAG antibodies has previously been reported in a single case. Our present case, at neuropathological examination, demonstrated no causative link between anti-MAG antibodies and ALS.

摘要

我们报告了一例71岁女性患者，患有典型的延髓性肌萎缩侧索硬化症（ALS），伴有免疫球蛋白M（IgM）单克隆丙种球蛋白病和抗髓鞘相关糖蛋白（MAG）抗体。ALS与抗MAG抗体之间这种不寻常的关联此前仅在一例病例中有过报道。在我们目前的这个病例中，神经病理学检查显示抗MAG抗体与ALS之间不存在因果联系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53cd/3250649/1190e82086ed/crn0003-0294-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53cd/3250649/1190e82086ed/crn0003-0294-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53cd/3250649/1190e82086ed/crn0003-0294-f01.jpg

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本文引用的文献

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Amyotrophic lateral sclerosis with sensory neuropathy: part of a multisystem disorder?伴感觉神经病的肌萎缩侧索硬化症：多系统疾病的一部分？
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Predictors of response to rituximab in patients with neuropathy and anti-myelin associated glycoprotein immunoglobulin M.
伴有神经病和抗髓鞘相关糖蛋白免疫球蛋白M的患者对利妥昔单抗反应的预测因素
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IgM paraproteinaemic neuropathies.IgM 副蛋白血症性神经病
Curr Opin Neurol. 2004 Oct;17(5):599-605. doi: 10.1097/00019052-200410000-00010.
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Amyotrophic lateral sclerosis.肌萎缩侧索硬化症
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