Rowland L P, Sherman W L, Hays A P, Lange D J, Latov N, Trojaborg W, Younger D S
Department of Neurology, Columbia-Presbyterian Medical Center, New York, NY 10032-2603, USA.
Neurology. 1995 Apr;45(4):827-9. doi: 10.1212/wnl.45.4.827.
Antibodies to myelin-associated glycoprotein (MAG) are found in patients with both monoclonal gammopathy and sensorimotor peripheral neuropathy but almost never in patients with amyotrophic lateral sclerosis (ALS). Ninety percent of patients with anti-MAG activity also have antibodies to sulfated glucuronic acid paragloboside (SGPG). We studied a patient with autopsy-proven ALS who had high titers of anti-SGPG but normal anti-MAG--one more unexplained immunologic abnormality in ALS.
在患有单克隆丙种球蛋白病和感觉运动性周围神经病的患者中可发现抗髓鞘相关糖蛋白（MAG）抗体，但在肌萎缩侧索硬化症（ALS）患者中几乎从未发现。90%具有抗MAG活性的患者也有抗硫酸化葡糖醛酸副球蛋白（SGPG）抗体。我们研究了一名经尸检证实患有ALS的患者，其抗SGPG滴度很高，但抗MAG正常——这是ALS中又一个无法解释的免疫异常情况。
