混合性冷球蛋白血症背景下由外伤引发的周边溃疡性角膜炎和坏死性巩膜炎。
Peripheral ulcerative keratitis and necrotizing scleritis initiated by trauma in the setting of mixed cryoglobulinemia.
作者信息
Johnson Cameron Campbell, Ohlstein Derek Hunter
机构信息
University of Florida, Department of Ophthalmology, Gainesville, Fla., USA.
出版信息
Case Rep Ophthalmol. 2011 Sep;2(3):392-7. doi: 10.1159/000334496. Epub 2011 Dec 12.
PURPOSE
To report a case of peripheral ulcerative keratitis and necrotizing scleritis precipitated by trauma in a patient with mixed cryoglobulinemia due to hepatitis C viral infection.
METHODS
Case report and literature review.
RESULTS
A 62-year-old man with a history of mixed cryoglobulinemia developed an episode of necrotizing scleritis and peripheral ulcerative keratitis one month after repair of a traumatic scleral defect with patch grafting. This episode resolved following treatment with high-dose corticosteroids and the patient underwent successful repeat patch grafting along with a free conjunctival autograft. This is the second reported case of necrotizing scleritis and peripheral ulcerative keratitis associated with mixed cryoglobulinemia.
CONCLUSION
Ophthalmologists should be aware of the association between mixed cryoglobulinemia and necrotizing scleritis/peripheral ulcerative keratitis. Patients with this condition experiencing ocular trauma or undergoing ocular surgery should be monitored closely.
目的
报告1例丙型肝炎病毒感染所致混合性冷球蛋白血症患者因外伤引发周边溃疡性角膜炎和坏死性巩膜炎的病例。
方法
病例报告及文献复习。
结果
1例有混合性冷球蛋白血症病史的62岁男性患者，在采用补片移植修复外伤性巩膜缺损1个月后发生坏死性巩膜炎和周边溃疡性角膜炎。经大剂量皮质类固醇治疗后病情缓解，患者成功接受了再次补片移植及游离结膜自体移植。这是第二例报告的与混合性冷球蛋白血症相关的坏死性巩膜炎和周边溃疡性角膜炎病例。
结论
眼科医生应了解混合性冷球蛋白血症与坏死性巩膜炎/周边溃疡性角膜炎之间的关联。患有这种疾病且遭受眼外伤或接受眼科手术的患者应密切监测。
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