Skanjeti Andrea, Pelosi Ettore
SCDU Medicina Nucleare 2, ASO S. Giovanni Battista, Corso Bramante, 88, 10126 Torino, Italy.
ISRN Oncol. 2011;2011:219064. doi: 10.5402/2011/219064. Epub 2011 Dec 18.
Due to its prevalence, prostate cancer represents a serious health problem. The treatment, when required, may be local in case of limited disease, locoregional if lymph nodes are involved, and systemic when distant metastases are present. In order to choose the best treatment regimen, an accurate disease staging is mandatory. However, the accuracy of conventional imaging modalities in detecting lymph node and bone metastases is low. In the last decade, molecular imaging, particularly, choline PET-CT has been evaluated in this setting. Choline PET represents the more accurate exam to stage high-risk prostate cancer, and it is useful in staging patients with biochemical relapse, in particular when PSA kinetics is high and/or PSA levels are more than 2 pg/ml. The present paper reports results of available papers on these issues, with particular attention to lymph node staging.
由于其高发性，前列腺癌是一个严重的健康问题。如有必要，对于疾病局限的情况，治疗可能是局部性的；若淋巴结受累，则是局部区域治疗；当出现远处转移时，则是全身性治疗。为了选择最佳治疗方案，准确的疾病分期是必不可少的。然而，传统成像方式在检测淋巴结和骨转移方面的准确性较低。在过去十年中，分子成像，特别是胆碱PET-CT已在此背景下得到评估。胆碱PET是对高危前列腺癌进行分期的更准确检查，对生化复发患者的分期很有用，特别是当PSA动力学较高和/或PSA水平超过2 pg/ml时。本文报告了关于这些问题的现有文献结果，特别关注淋巴结分期。
