Vlachostergios Panagiotis J, Karasavvidou Foteini, Kakkas Grigorios, Kapatou Kassiani, Gioulbasanis Ioannis, Daliani Danai D, Moutzouris George, Papandreou Christos N
Department of Medical Oncology, University Hospital of Larissa, University of Thessaly School of Medicine, Larissa, Greece.
J Negat Results Biomed. 2012 Jan 5;11(1):2. doi: 10.1186/1477-5751-11-2.
Loss of normal cell cycle control is an early event in the evolution of cancer. The expression of cyclin-dependent kinase (CDK) inhibitors p16 and p27 has been previously associated with progression of prostate cancer (PC). 70 patients diagnosed with early stage PCwere treated with radical prostatectomy (RP) at our institution and their tumor specimens were immunohistochemically evaluated for expression of p16 and p27. Available clinical data of time to PSA recurrence were correlated with the examined parameters and combined with pre-operative PSA level, Gleason score and pathological TNM (pT) stage assessment.
Nuclear overexpression of p16 was not associated with time to biochemical failure (BF) (p = 0.572). Same was the case for nuclear p27 overexpression (p = 1.000). Also, no significant correlations were found between either p16 or p27, and pre-operative PSA level, pT stage and Gleason grade. pT stage emerged as the only independent prognostic factor for biochemical recurrence (p = 0.01).
These data question previously reported data supporting the prognostic relevance of both p16 and p27 proteins in early PC.
正常细胞周期调控的丧失是癌症发生发展早期的一个事件。细胞周期蛋白依赖性激酶（CDK）抑制剂p16和p27的表达先前已与前列腺癌（PC）的进展相关。在我们机构，70例被诊断为早期PC的患者接受了根治性前列腺切除术（RP），并对其肿瘤标本进行p16和p27表达的免疫组织化学评估。将可获得的前列腺特异性抗原（PSA）复发时间的临床数据与检测参数相关联，并结合术前PSA水平、 Gleason评分和病理TNM（pT）分期评估。
p16核过表达与生化失败（BF）时间无关（p = 0.572）。核p27过表达情况相同（p = 1.000）。此外，在p16或p27与术前PSA水平、pT分期和Gleason分级之间均未发现显著相关性。pT分期是生化复发的唯一独立预后因素（p = 0.01）。
这些数据对先前报道的支持p16和p27蛋白在早期PC中具有预后相关性的数据提出了质疑。
