形成β桶：革兰氏阴性菌中外膜蛋白的组装。
Making a beta-barrel: assembly of outer membrane proteins in Gram-negative bacteria.
机构信息
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, United States.
出版信息
Curr Opin Microbiol. 2012 Apr;15(2):189-93. doi: 10.1016/j.mib.2011.12.007. Epub 2012 Jan 3.
Abstract
The outer membrane (OM) of Gram-negative bacteria is an essential organelle that serves as a selective permeability barrier by keeping toxic compounds out of the cell while allowing vital nutrients in. How the OM and its constituent lipid and protein components are assembled remains an area of active research. In this review, we describe our current understanding of how outer membrane proteins (OMPs) are delivered to and then assembled in the OM of the model Gram-negative organism Escherichia coli.
摘要
革兰氏阴性菌的外膜（OM）是一种重要的细胞器，它作为一种选择性渗透屏障，将有毒化合物拒之细胞之外，同时允许重要的营养物质进入细胞。OM 及其组成的脂质和蛋白质成分是如何组装的，这仍然是一个活跃的研究领域。在这篇综述中，我们描述了我们目前对模型革兰氏阴性菌大肠杆菌中 OM 中 OMPs 的递呈和组装的理解。
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